RAD21 cohesin complex component
Última atualização 13 Abr 2022
Atende aos diretrizes editoriais
- BaixarBaixar
- Compartilhar
- Language
- Discussão
- Versão em Áudio
- Adicionar às fontes preferidas no Google
The RAD21 gene provides instructions for making a protein that is involved in regulating the structure and organisation of chromosomes during cell division.
Normal function
The RAD21 gene provides instructions for making a protein that is involved in regulating the structure and organisation of chromosomes during cell division.
Before cells divide, they must copy all of their chromosomes. The copied DNA from each chromosome is arranged into two identical structures, called sister chromatids, which are attached to one another during the early stages of cell division. The RAD21 protein is part of a protein group called the cohesin complex that holds the sister chromatids together.
Researchers believe that the RAD21 protein, as a structural component of the cohesin complex, also plays important roles in stabilizing cells' genetic information, repairing damaged DNA, and regulating the activity of certain genes that are essential for normal development.
Conditions referring to this gene or chromosome
Other names
CDLS4
double-strand-break repair protein rad21 homolog
hHR21
HR21
HRAD21
KIAA0078
kleisin
MCD1
nuclear matrix protein 1
NXP-1
NXP1
RAD21 homolog
SCC1
SCC1 homolog
sister chromatid cohesion 1
Related patient information and medicines
Patient information leaflet
Posso tomar Amlodipina e Nustendi juntos?
Tomar amlodipine and Nustendi ( ezetimibe ) together can increase the amount of one of the ingredients in Nustendi (bempedoic acid) in your bloodstream. Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, e suplementos são safe to uma together. Simply search for your medicines to see.
Patient information leaflet
Posso tomar Turkey tail e White button juntos?
Why this happens Both mushrooms contain bioactive compounds called polysaccharides (such as beta-glucans). Rather than interfering with each other, they may have a complementary effect on the immune system without affecting how the body absorbs or processes eithe... General Food Intake These medicinal mushrooms contain complex polysaccharides.
Patient information leaflet
Posso tomar Shiitake e Turkey tail juntos?
Both alcohol and certain compounds in these mushrooms are processed by the liver; combining them may increase the strain on your liver or alter how the supplements ... General Food Intake These medicinal mushrooms contain complex polysaccharides (beta-glucans). For the best absorption, it is often recommended to take them on an empty stomach, at.
Patient information leaflet
Posso tomar Royal sun e White button juntos?
Both Royal Sun (Agaricus blazei) and White Button mushrooms contain compounds that may lower blood sugar levels. General Food Intake These medicinal mushrooms contain complex polysaccharides (beta-glucans). Our Verificador de Interações de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements são safe to take.
Patient information leaflet
Posso tomar Royal sun e Turkey tail juntos?
Ambos Royal Sun (Agaricus blazei) and Turkey Tail (Trametes versicolor) são medicinal mushrooms that can stimulate the immune system. T... General Food Intake These medicinal mushrooms contain complex polysaccharides (beta-glucans). Aviso Legal Este information é for general educational purposes only and should not be relied upon as a substitute.
Patient information leaflet
Posso tomar Royal sun e Shiitake juntos?
Both Royal Sun (Agaricus blazei) and Shiitake (Lentinula edodes) mushrooms contain high levels of beta-glucans, which are substances that stimulate the immune system. Taking them together may cause your immune system to ... Our Verificador de Interações de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, e suplementos are.
Leitura adicional e referências
- RAD21 cohesin complex component; MedlinePlus, National Library of Medicine.
- Deardorff MA, Wilde JJ, Albrecht M, Dickinson E, Tennstedt S, Braunholz D, Monnich M, Yan Y, Xu W, Gil-Rodriguez MC, Clark D, Hakonarson H, Halbach S, Michelis LD, Rampuria A, Rossier E, Spranger S, Van Maldergem L, Lynch SA, Gillessen-Kaesbach G, Ludecke HJ, Ramsay RG, McKay MJ, Krantz ID, Xu H, Horsfield JA, Kaiser FJ. RAD21 mutations cause a human cohesinopathy. Am J Hum Genet. 2012 Jun 8;90(6):1014-27. doi: 10.1016/j.ajhg.2012.04.019. Epub 2012 May 24.
- Maas SM, Shaw AC, Bikker H, Ludecke HJ, van der Tuin K, Badura-Stronka M, Belligni E, Biamino E, Bonati MT, Carvalho DR, Cobben J, de Man SA, Den Hollander NS, Di Donato N, Garavelli L, Gronborg S, Herkert JC, Hoogeboom AJ, Jamsheer A, Latos-Bielenska A, Maat-Kievit A, Magnani C, Marcelis C, Mathijssen IB, Nielsen M, Otten E, Ousager LB, Pilch J, Plomp A, Poke G, Poluha A, Posmyk R, Rieubland C, Silengo M, Simon M, Steichen E, Stumpel C, Szakszon K, Polonkai E, van den Ende J, van der Steen A, van Essen T, van Haeringen A, van Hagen JM, Verheij JB, Mannens MM, Hennekam RC. Phenotype and genotype in 103 patients with tricho-rhino-phalangeal syndrome. Eur J Med Genet. 2015 May;58(5):279-92. doi: 10.1016/j.ejmg.2015.03.002. Epub 2015 Mar 16.
- McKay MJ, Troelstra C, van der Spek P, Kanaar R, Smit B, Hagemeijer A, Bootsma D, Hoeijmakers JH. Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse. Genomics. 1996 Sep 1;36(2):305-15. doi: 10.1006/geno.1996.0466.
- Minor A, Shinawi M, Hogue JS, Vineyard M, Hamlin DR, Tan C, Donato K, Wysinger L, Botes S, Das S, Del Gaudio D. Two novel RAD21 mutations in patients with mild Cornelia de Lange syndrome-like presentation and report of the first familial case. Gene. 2014 Mar 10;537(2):279-84. doi: 10.1016/j.gene.2013.12.045. Epub 2013 Dec 27.
- Sonoda E, Matsusaka T, Morrison C, Vagnarelli P, Hoshi O, Ushiki T, Nojima K, Fukagawa T, Waizenegger IC, Peters JM, Earnshaw WC, Takeda S. Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells. Dev Cell. 2001 Dec;1(6):759-70. doi: 10.1016/s1534-5807(01)00088-0.
Participe da conversa
Compartilhe seus pensamentos ou experiências com outros em nosso comunidades de pacientes.
Pergunte, compartilhe, conecte-se.
Navegue por discussões, faça perguntas e compartilhe experiências em centenas de tópicos de saúde.
Inscreva-se no boletim informativo do Patient
Sua dose semanal de conselhos de saúde claros e confiáveis - escritos para ajudá-lo a se sentir informado, confiante e no controle.
Ao se inscrever, você aceita nossos Política de Privacidade. Você pode cancelar a inscrição a qualquer momento. Nunca vendemos seus dados.