miR-17-92a-1 cluster host gene
Última atualização 14 Apr 2023
Atende aos diretrizes editoriais
- BaixarBaixar
- Compartilhar
- Language
- Discussão
- Versão em Áudio
- Adicionar às fontes preferidas no Google
A MIR17HG gene provides instructions for making the miR-17~92 microRNA (miRNA) cluster. MiRNAs are short pieces of RNA, a chemical cousin of DNA. These molecules control gene expression by blocking protein production. The miR-17~92 cluster includes six miRNAs: miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, and miR-92a-1. MiRNAs in this cluster control the expression of hundreds of genes. These miRNAs help regulate signaling pathways that direct several cellular processes involved in growth and development, including cell growth and division (proliferation), cell maturation (differentiation), and the self-destruction of cells (apoptosis). Studies suggest that the miR-17~92 cluster is necessary for normal development of the skeleton, heart, kidneys, lungs, and nervous system.
Normal function
A MIR17HG gene provides instructions for making the miR-17~92 microRNA (miRNA) cluster. MiRNAs are short pieces of RNA, a chemical cousin of DNA. These molecules control gene expression by blocking protein production. The miR-17~92 cluster includes six miRNAs: miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, and miR-92a-1. MiRNAs in this cluster control the expression of hundreds of genes. These miRNAs help regulate signaling pathways that direct several cellular processes involved in growth and development, including cell growth and division (proliferation), cell maturation (differentiation), and the self-destruction of cells (apoptosis). Studies suggest that the miR-17~92 cluster is necessary for normal development of the skeleton, heart, kidneys, lungs, and nervous system.
A MIR17HG gene belongs to a class of genes known as oncogenes. When mutated, oncogenes have the potential to cause normal cells to become cancerous.
Conditions referring to this gene or chromosome
Other names
C13orf25
FGLDS2
FLJ14178
LINC00048
MIHG1
miR-17-92
MIRH1
MIRHG1
NCRNA00048
Related patient information and medicines
Patient information leaflet
Enxaqueca
...e vs. cluster headaches Cluster headachesTypically, cluster headaches: Cause very severe headaches or head pain, usually felt around one eye or over the temple on one side. Migraines are one of the "primary" headache disorders. Recent research has looked at the role of calcitonin gene-related peptide (CGRP) in migraine development. It's.
Patient information leaflet
Testes genéticos
Testes genéticos is a type of medical test that identifies changes in chromosomes, genes ou proteins. Genetic tests examine a person's DNA in a variety of ways to assess a person's genetic health. They are all designed to identify a particular gene that may cause a genetic disorder. We all have 46 chromosomes in our cells. Chromosomes are made from.
Patient information leaflet
Cefaleias em salvas
Cluster headaches occur as attacks of severe, one-sided headaches. Typically, a number of attacks occur over several weeks - a bout (cluster) of attacks. They are significantly more common in people who smoke, and tend to be more severe in smokers. There is also a genetic link with some people (about 1 in 20 people with cluster headaches have.
Patient information leaflet
Posso tomar Mirtazapina e Sertralina juntos?
Taking mirtazapine and sertraline together pode lead to a rare but serious condition called síndrome serotoninérgica. This happens because both medicines increase the levels of a chemical called serotonin in your brain. If levels get too ... Patients under 25 are at higher risk. Agranulocytosis (low white blood cell count) Mirtazapine can rarely cause a.
Patient information leaflet
Doença de Hirschsprung
Doença de Hirschsprung is a condition where some of the nerves are missing in a part of the bowel (gut). As a result the bowel muscles can't squeeze properly in that part of the gut. So they can't force the poo through that bit of gut. The poo gets stuck causing a blockage (obstruction). This problem is usually quite apparent early on in life as.
Patient information leaflet
Posso tomar Mirabegrona e Rivaroxabana juntos?
Taking these two medicines together... Why this happens Mirabegron and rivaroxaban are processed by different pathways in the body. Mirabegron é primarily broken down by enzymes called CYP3A4 and CYP2D6, while rivaroxaban is processed by CYP3A4 and a transport protein called P-gp. While they share the CYP3A4 pathway, studies show that mirabegron.
Leitura adicional e referências
- miR-17-92a-1 cluster host gene; MedlinePlus, National Library of Medicine.
- de Pontual L, Yao E, Callier P, Faivre L, Drouin V, Cariou S, Van Haeringen A, Genevieve D, Goldenberg A, Oufadem M, Manouvrier S, Munnich A, Vidigal JA, Vekemans M, Lyonnet S, Henrion-Caude A, Ventura A, Amiel J. Germline deletion of the miR-17 approximately 92 cluster causes skeletal and growth defects in humans. Nat Genet. 2011 Sep 4;43(10):1026-30. doi: 10.1038/ng.915.
- Fang LL, Wang XH, Sun BF, Zhang XD, Zhu XH, Yu ZJ, Luo H. Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review). Int J Mol Med. 2017 Dec;40(6):1624-1630. doi: 10.3892/ijmm.2017.3164. Epub 2017 Sep 29.
- Grote LE, Repnikova EA, Amudhavalli SM. Expanding the phenotype of feingold syndrome-2. Am J Med Genet A. 2015 Dec;167A(12):3219-25. doi: 10.1002/ajmg.a.37368. Epub 2015 Sep 11.
- Hemmat M, Rumple MJ, Mahon LW, Strom CM, Anguiano A, Talai M, Nguyen B, Boyar FZ. Short stature, digit anomalies and dysmorphic facial features are associated with the duplication of miR-17 ~ 92 cluster. Mol Cytogenet. 2014 Apr 16;7:27. doi: 10.1186/1755-8166-7-27. eCollection 2014.
- Kannu P, Campos-Xavier AB, Hull D, Martinet D, Ballhausen D, Bonafe L. Post-axial polydactyly type A2, overgrowth and autistic traits associated with a chromosome 13q31.3 microduplication encompassing miR-17-92 and GPC5. Eur J Med Genet. 2013 Aug;56(8):452-7. doi: 10.1016/j.ejmg.2013.06.001. Epub 2013 Jun 20.
- Mirzamohammadi F, Kozlova A, Papaioannou G, Paltrinieri E, Ayturk UM, Kobayashi T. Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. Nat Commun. 2018 Apr 10;9(1):1352. doi: 10.1038/s41467-018-03788-7.
- Mogilyansky E, Rigoutsos I. The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease. Cell Death Differ. 2013 Dec;20(12):1603-14. doi: 10.1038/cdd.2013.125.
Participe da conversa
Compartilhe seus pensamentos ou experiências com outros em nosso comunidades de pacientes.
Pergunte, compartilhe, conecte-se.
Navegue por discussões, faça perguntas e compartilhe experiências em centenas de tópicos de saúde.
Inscreva-se no boletim informativo do Patient
Sua dose semanal de conselhos de saúde claros e confiáveis - escritos para ajudá-lo a se sentir informado, confiante e no controle.
Ao se inscrever, você aceita nossos Política de Privacidade. Você pode cancelar a inscrição a qualquer momento. Nunca vendemos seus dados.