hyperpolarization activated cyclic nucleotide gated potassium channel 4
Última atualização 18 de ago de 2020
Atende aos diretrizes editoriais
- BaixarBaixar
- Compartilhar
- Language
- Discussão
- Versão em Áudio
- Adicionar às fontes preferidas no Google
A HCN4 gene provides instructions for making a channel that transports positively charged atoms (ions) into heart muscle cells. This channel is located primarily in the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The HCN4 channel allows potassium and sodium ions to flow into cells of the SA node. This ion flow is often called the "pacemaker current" because it generates electrical impulses that start each heartbeat and is involved in maintaining a regular heart rhythm.
Normal function
A HCN4 gene provides instructions for making a channel that transports positively charged atoms (ions) into heart muscle cells. This channel is located primarily in the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker. The HCN4 channel allows potassium and sodium ions to flow into cells of the SA node. This ion flow is often called the "pacemaker current" because it generates electrical impulses that start each heartbeat and is involved in maintaining a regular heart rhythm.
Conditions referring to this gene or chromosome
Other names
HCN4_HUMAN
hyperpolarization activated cyclic nucleotide-gated cation channel 4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
SSS2
Related patient information and medicines
Patient information leaflet
Dieta na doença renal crônica
Há alguns dietary choices that are recommended for people with early CKD. People with more advanced CKD may be advised to follow a special diet, usually with the support of a specialist dietician. If your kidney function is becoming worse (stage 4 to 5), you will probably be referred to a specialist in renal (kidney) medicine. S... Low.
Patient information leaflet
Posso tomar Candesartan e Eplerenona juntos?
Taking these two medicines together can significantly increase the level of potassium in your blood (a condition called hyperkalaemia). While both drugs are used to treat heart conditions or high blood pressure, having too much potassium can be dangerous and may lead to serious heart rhythm problems. Why this happens Both candesartan and.
Patient information leaflet
Posso tomar Bisoprolol e Ramipril juntos?
It can also occasionally lead to increased levels of po... Why this happens Both medicines work to lower blood pressure but in different ways. Bisoprolol is a beta-blocker that slows the heart rate, while ramipril is an ACE inhibitor that relaxes blood vessels. Because they both target the cardiovascular system, their effects add together (an.
Patient information leaflet
Posso tomar Candesartana e Rosuvastatina juntos?
Drinking large amounts of alcohol regularly or binge drinking can increase your risk of serious muscle problems and liver damage. Potassium-rich foods (e.g., bananas, spinach, salt substitutes) Candesartan can increase the levels of potassium in your blood. Consuming large amounts of foods very high in potassium or using potassium-based salt.
Patient information leaflet
Posso tomar Candesartan e Matcha juntos?
It can cause serious harm or death to an unborn baby, especially if used during the second and third trimesters. Use effective contraception while taking it. High potassium (Hyperkalaemia) Candesartan increases potassium levels in your blood. Matcha also contains significant potassium. Avoid using potassium supplements or salt substitutes.
Patient information leaflet
Posso tomar Bisoprolol e Losartan juntos?
Tomar bisoprolol and losartan together can cause your blood pressure to drop lower than intended. This may make you feel dizzy, lightheaded, or faint, especially when standing up quickly. Why this happens Both medicines work to lower blood pressure but in different ways. Bisoprolol is a beta-blocker that slows the heart rate, while losartan is an.
Leitura adicional e referências
- hyperpolarization activated cyclic nucleotide gated potassium channel 4; MedlinePlus, National Library of Medicine.
- Baruscotti M, Bottelli G, Milanesi R, DiFrancesco JC, DiFrancesco D. HCN-related channelopathies. Pflugers Arch. 2010 Jul;460(2):405-15. doi: 10.1007/s00424-010-0810-8. Epub 2010 Mar 8.
- Milanesi R, Baruscotti M, Gnecchi-Ruscone T, DiFrancesco D. Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel. N Engl J Med. 2006 Jan 12;354(2):151-7. doi: 10.1056/NEJMoa052475.
- Netter MF, Zuzarte M, Schlichthorl G, Klocker N, Decher N. The HCN4 channel mutation D553N associated with bradycardia has a C-linker mediated gating defect. Cell Physiol Biochem. 2012;30(5):1227-40. doi: 10.1159/000343314. Epub 2012 Oct 15.
- Nof E, Luria D, Brass D, Marek D, Lahat H, Reznik-Wolf H, Pras E, Dascal N, Eldar M, Glikson M. Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia. Circulation. 2007 Jul 31;116(5):463-70. doi: 10.1161/CIRCULATIONAHA.107.706887. Epub 2007 Jul 23.
- Ueda K, Hirano Y, Higashiuesato Y, Aizawa Y, Hayashi T, Inagaki N, Tana T, Ohya Y, Takishita S, Muratani H, Hiraoka M, Kimura A. Role of HCN4 channel in preventing ventricular arrhythmia. J Hum Genet. 2009 Feb;54(2):115-21. doi: 10.1038/jhg.2008.16. Epub 2009 Jan 23.
- Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesato Y, Hirano Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A. Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia. J Biol Chem. 2004 Jun 25;279(26):27194-8. doi: 10.1074/jbc.M311953200. Epub 2004 Apr 30.
Participe da conversa
Compartilhe seus pensamentos ou experiências com outros em nosso comunidades de pacientes.
Pergunte, compartilhe, conecte-se.
Navegue por discussões, faça perguntas e compartilhe experiências em centenas de tópicos de saúde.
Inscreva-se no boletim informativo do Patient
Sua dose semanal de conselhos de saúde claros e confiáveis - escritos para ajudá-lo a se sentir informado, confiante e no controle.
Ao se inscrever, você aceita nossos Política de Privacidade. Você pode cancelar a inscrição a qualquer momento. Nunca vendemos seus dados.