eukaryotic translation initiation factor 2 alpha kinase 4
Última atualização 10 Apr 2023
Atende aos diretrizes editoriais
- BaixarBaixar
- Compartilhar
- Language
- Discussão
- Versão em Áudio
- Adicionar às fontes preferidas no Google
A EIF2AK4 gene provides instructions for making a protein that helps direct a cell's response to changes that could damage the cell. This protein is found in several tissues throughout the body, including blood vessel walls. The EIF2AK4 protein can turn on (activate) another protein called eIF2 alpha (eIF2α), which helps control protein production. When cells are under stress, for example when the level of protein building blocks (amino acids) is too low, EIF2AK4 activates eIF2α. When turned on, eIF2α stimulates processes that reduce protein production, which helps conserve amino acids. In addition, activated eIF2α can trigger production of certain proteins called transcription factors, which control gene activity. The transcription factors regulated by eIF2α control the activity of genes involved in processes that help reduce the stress on the cell.
Normal function
A EIF2AK4 gene provides instructions for making a protein that helps direct a cell's response to changes that could damage the cell. This protein is found in several tissues throughout the body, including blood vessel walls. The EIF2AK4 protein can turn on (activate) another protein called eIF2 alpha (eIF2α), which helps control protein production. When cells are under stress, for example when the level of protein building blocks (amino acids) is too low, EIF2AK4 activates eIF2α. When turned on, eIF2α stimulates processes that reduce protein production, which helps conserve amino acids. In addition, activated eIF2α can trigger production of certain proteins called transcription factors, which control gene activity. The transcription factors regulated by eIF2α control the activity of genes involved in processes that help reduce the stress on the cell.
Conditions referring to this gene or chromosome
Other names
E2AK4_HUMAN
eukaryotic translation initiation factor 2-alpha kinase 4
GCN2
GCN2 eIF2alpha kinase
GCN2-like protein
general control nonderepressible 2
KIAA1338
PVOD2
Related patient information and medicines
Patient information leaflet
Mielofibrose
Mielofibrose is a serious bone marrow disorder that disrupts your body's normal production of blood cells. This leads to reduced levels of: Red blood cells (erythrocytes). This causes anaemia. It's not known what causes the genetic mutation in blood stem cells. The gene mutation that occurs in most people affected by mielofibrose is a mutation.
Patient information leaflet
Distúrbios de armazenamento de glicogênio
Distúrbios de armazenamento de glicogênio are a group of inherited diseases. They result from a problem with one of the proteins (known as enzymes) involved in the conversion of glucose to glycogen, or the breakdown of glycogen back into glucose. They mostly tend to affect your liver and muscles. Most are diagnosed in childhood. Symptoms include weakness,.
Patient information leaflet
Câncer primário de fígado
This can be due to the growing cancer itself. It may also be due to ascites - fluid that builds up in the abdomen - which occurs with various liver disorders. What causes primary liver cancer. A cancerous (malignant) tumour starts from one abnormal cell. The exact reason why a cell becomes cancerous is unclear. It is thought that something damages.
Patient information leaflet
Testes de função hepática
What are the main liver function tests. The usual liver function tests typically include the following: Bilirubin. Albumin. Total protein. Transferases (AST or SGOT and ALT or SGPT). Gamma GT. Creatine kinase. Prothrombin time or International Normalised Ratio (INR). Each of these is discussed below. The liver performs hundreds of different.
Patient information leaflet
Câncer de boca
Câncer de boca is also sometimes called oral cancer. Worldwide it is the sixth most common cancer. Although mouth cancer is uncommon in the UK, it seems to be getting much more common: the number of cases doubled in the 20 years from 1994 to 2014. There are around 7,500 cases diagnosed each year in the UK. It is twice as common in men as it is in.
Patient information leaflet
Fatos e fatores de risco do câncer de mama
Most cases of breast cancer occur by chance. However, breast cancer does occur more often than usual in some families because of their genetic makeup. Most cases of breast cancer occur by chance. However, breast cancer does occur more often than usual in some families because of their genetic makeup. Genetic means that the condition is passed on.
Leitura adicional e referências
- eukaryotic translation initiation factor 2 alpha kinase 4; MedlinePlus, National Library of Medicine.
- Deval C, Chaveroux C, Maurin AC, Cherasse Y, Parry L, Carraro V, Milenkovic D, Ferrara M, Bruhat A, Jousse C, Fafournoux P. Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways. FEBS J. 2009 Feb;276(3):707-18. doi: 10.1111/j.1742-4658.2008.06818.x. Epub 2008 Dec 19.
- Donnelly N, Gorman AM, Gupta S, Samali A. The eIF2alpha kinases: their structures and functions. Cell Mol Life Sci. 2013 Oct;70(19):3493-511. doi: 10.1007/s00018-012-1252-6. Epub 2013 Jan 26.
- Eyries M, Montani D, Girerd B, Perret C, Leroy A, Lonjou C, Chelghoum N, Coulet F, Bonnet D, Dorfmuller P, Fadel E, Sitbon O, Simonneau G, Tregouet DA, Humbert M, Soubrier F. EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension. Nat Genet. 2014 Jan;46(1):65-9. doi: 10.1038/ng.2844. Epub 2013 Dec 1.
- Murguia JR, Serrano R. New functions of protein kinase Gcn2 in yeast and mammals. IUBMB Life. 2012 Dec;64(12):971-4. doi: 10.1002/iub.1090. Epub 2012 Nov 5.
Participe da conversa
Compartilhe seus pensamentos ou experiências com outros em nosso comunidades de pacientes.
Pergunte, compartilhe, conecte-se.
Navegue por discussões, faça perguntas e compartilhe experiências em centenas de tópicos de saúde.
Inscreva-se no boletim informativo do Patient
Sua dose semanal de conselhos de saúde claros e confiáveis - escritos para ajudá-lo a se sentir informado, confiante e no controle.
Ao se inscrever, você aceita nossos Política de Privacidade. Você pode cancelar a inscrição a qualquer momento. Nunca vendemos seus dados.