B-Raf proto-oncogene, serine/threonine kinase
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A BRAF gene provides instructions for making a protein that helps transmit chemical signals from outside the cell to the cell's nucleus. This protein is part of a signaling pathway known as the RAS/MAPK pathway, which controls several important cell functions. Specifically, the RAS/MAPK pathway regulates the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (migration), and the self-destruction of cells (apoptosis). Chemical signaling through this pathway is essential for normal development before birth.
Normal function
A BRAF gene provides instructions for making a protein that helps transmit chemical signals from outside the cell to the cell's nucleus. This protein is part of a signaling pathway known as the RAS/MAPK pathway, which controls several important cell functions. Specifically, the RAS/MAPK pathway regulates the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (migration), and the self-destruction of cells (apoptosis). Chemical signaling through this pathway is essential for normal development before birth.
A BRAF gene belongs to a class of genes known as oncogenes. When mutated, oncogenes have the potential to cause normal cells to become cancerous.
Conditions referring to this gene or chromosome
Other names
94 kDa B-raf protein
B-raf 1
B-Raf proto-oncogene serine/threonine-protein kinase
BRAF1
BRAF1_HUMAN
Murine sarcoma viral (v-raf) oncogene homolog B1
p94
RAFB1
v-raf murine sarcoma viral oncogene homolog B
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Leitura adicional e referências
- B-Raf proto-oncogene, serine/threonine kinase; MedlinePlus, National Library of Medicine.
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