Can I take St John's wort and Fluoxetine together?

Por que isso acontece

Both fluoxetine and St John's Wort work by increasing the levels of serotonin in the brain. When used together, they can raise these levels too high (a 'pharmacodynamic' interaction). Additionally, St John's Wort can change how the liver breaks down certain medicines, which can make the levels of fluoxetine in your blood unpredictable.

Do NOT take St John's Wort if you are already taking fluoxetine (Prozac). If you are currently taking both, you should contact your GP or pharmacist immediately for advice before stopping either, as stopping antidepressants suddenly can also cause side effects. If you experience severe symptoms like confusion, high fever, or tremors, seek emergency medical help.

Síndrome da Serotonina

Taking fluoxetine and St John's wort together significantly increases the risk of serotonin syndrome, a potentially life-threatening condition caused by excessive serotonin levels. Symptoms include high fever, agitation, confusion, and muscle twitching. Do not combine these treatments.

Depression and Mental Health

Like other antidepressants, St John's wort and fluoxetine may increase the risk of suicidal thoughts or self-harm, particularly when first starting treatment. Seek immediate medical help if your mood worsens.

Drug Interactions

St John's wort significantly reduces the effectiveness of many essential medicines, including the contraceptive pill, blood thinners (warfarin), epilepsy medications, and organ transplant drugs. Do not start it without a pharmacist checking your current medications.

Risco de sangramento

Fluoxetine can increase your risk of bleeding, especially if you are also taking aspirin, NSAIDs (like ibuprofen), or blood-thinning medications (like warfarin). Seek medical advice if you notice unusual bruising or bleeding.

Photosensitivity

St John's wort can make your skin significantly more sensitive to sunlight, leading to severe sunburn or skin reactions even with limited exposure.

Álcool

It is best to avoid or strictly limit alcohol while taking these medicines. Combining alcohol with fluoxetine or St John's Wort can increase drowsiness and dizziness, and may worsen feelings of depression.

Cafeína (Café, Chá, Bebidas Energéticas)

Fluoxetine can increase the effects of caffeine in your body. This may lead to feeling jittery, anxious, or having difficulty sleeping.

Foods high in Tyramine (e.g., aged cheeses, cured meats, soy sauce, marmite, overripe fruit)

While less common than with older prescription antidepressants, St John's Wort can potentially interact with tyramine-rich foods, leading to a sudden, dangerous increase in blood pressure (hypertensive crisis). You should consume these foods in moderation.

Tomando vários medicamentos? Nosso Verificador de Interações de Medicamentos ajuda você a verificar se suas prescrições, medicamentos de venda livre e suplementos são seguros para serem tomados juntos. Basta procurar seus medicamentos para ver possíveis interações e o que fazer sobre elas.

Aviso Legal

Esta informação é apenas para fins educacionais gerais e não deve ser considerada como um substituto para aconselhamento médico profissional. Sempre consulte seu médico, farmacêutico ou outro profissional de saúde qualificado antes de tomar decisões sobre seus medicamentos. As circunstâncias individuais podem variar, e somente um profissional de saúde que conheça seu histórico médico pode fornecer orientações personalizadas.