Can I take Co-codamol and Naproxen together?
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Publicado originalmente 25 Jan 2026
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There is no direct harmful interaction between co-codamol and naproxen. In fact, they are often prescribed together to provide better pain relief than using one alone. However, because co-codamol contains paracetamol, you must be careful not to take any other products containing paracetamol at the same time.
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Por que isso acontece
These medicines work in different ways to target pain. Naproxen is an anti-inflammatory (NSAID) that reduces swelling and pain at the source, while co-codamol (a mix of paracetamol and codeine) works on the central nervous system to change how your body feels and responds to pain. They do not interfere with how the body absorbs or breaks down one another.
O que você deve fazer
Voltar ao conteúdoIt is generally safe to take these together if prescribed by a healthcare professional. Ensure you do not exceed the maximum daily dose of co-codamol, and do not take any other paracetamol-containing products (like Lemsip or certain cold cures). To protect your stomach, always take naproxen with or after food. If you experience any stomach pain or dark, tarry stools, stop taking naproxen and contact your doctor.
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Precauções importantes
Voltar ao conteúdoParacetamol overdose
Co-codamol contains paracetamol. Do not take it with any other paracetamol-containing products (such as cold and flu remedies), as this can lead to fatal liver damage.
Opioid addiction and withdrawal
Co-codamol contains codeine, which can cause addiction if used for more than 3 days. Stopping suddenly after long-term use can cause withdrawal symptoms.
Asthma and breathing difficulties
Do not take co-codamol if you have severe asthma or breathing problems, as the codeine can dangerously slow your breathing.
Do not take naproxen if you have asthma that is worsened by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can trigger a severe or life-threatening asthma attack.
Stomach ulcers or bleeding
Naproxen significantly increases the risk of stomach ulcers and internal bleeding. Seek immediate medical help if you vomit blood or pass black, tarry stools.
Gravidez (terceiro trimestre)
Do not take naproxen if you are more than 20 weeks pregnant, as it can cause serious heart or kidney problems in the unborn baby and reduce amniotic fluid levels.
Avisos sobre alimentos e bebidas
Voltar ao conteúdoÁlcool
You must avoid drinking alcohol while taking co-codamol. Combining alcohol with codeine increases the risk of serious side effects, such as extreme sleepiness, breathing difficulties, and loss of consciousness. Additionally, both alcohol and paracetamol can affect the liver; combining them regularly increases the risk of liver damage. Drinking alcohol while taking naproxen can increase the risk of irritation to your stomach lining and may increase the risk of stomach ulcers or bleeding.
Cafeína
Some versions of co-codamol already contain caffeine. If you consume extra caffeine from coffee, tea, or energy drinks, it may make you feel shaky, anxious, or cause a racing heart.
Alimentação (Geral)
You should take naproxen with or just after a meal or a snack. This helps to protect your stomach lining and reduces the chance of indigestion or stomach pain.
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Usando outros medicamentos
Voltar ao conteúdoTomando vários medicamentos? Nosso Verificador de Interações de Medicamentos ajuda você a verificar se suas prescrições, medicamentos de venda livre e suplementos são seguros para serem tomados juntos. Basta procurar seus medicamentos para ver possíveis interações e o que fazer sobre elas.
Aviso Legal
Esta informação é apenas para fins educacionais gerais e não deve ser considerada como um substituto para aconselhamento médico profissional. Sempre consulte seu médico, farmacêutico ou outro profissional de saúde qualificado antes de tomar decisões sobre seus medicamentos. As circunstâncias individuais podem variar, e somente um profissional de saúde que conheça seu histórico médico pode fornecer orientações personalizadas.
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Can I take Hydroxycarbamide and Naproxen together?
Taking hydroxycarbamide and naproxen together can increase your risk of serious side effects, particularly affecting your blood counts and your kidneys. Both medications can lower the number of white blood cells and platelets in your body, making you more prone to infections and bruising or bleeding. Additionally, both drugs can put strain on the kidneys; naproxen can reduce blood flow to the kidneys, which may make it harder for your body to clear hydroxycarbamide, potentially leading to toxic levels of the medicine in your system.
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Histórico do artigo
As informações nesta página são escritas e revisadas por clínicos qualificados.
25 Jan 2026 | Publicado originalmente

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