Can I take Black cohosh and Glucosamine together?

Why this happens

These two substances are processed by the body through different pathways. Glucosamine is an amino sugar used by the body to build cartilage, while black cohosh is a herbal remedy that primarily affects hormonal pathways or neurotransmitters. They do not compete for the same enzymes in the liver (such as the Cytochrome P450 system) to a degree that would cause a dangerous buildup of either substance.

What you should do

You can take these two supplements together. However, as with any supplement regime, you should monitor how you feel. If you have liver problems, consult your doctor before taking black cohosh, as it has been linked to rare cases of liver inflammation. If you have a shellfish allergy, ensure your glucosamine is from a vegan or bovine source.

Important precautions

Pregnancy

Do not use black cohosh during pregnancy. It may stimulate uterine contractions, potentially increasing the risk of miscarriage or premature labour.

Liver disease

Black cohosh has been linked to rare but serious cases of liver failure. You must stop taking it and see a doctor immediately if you develop yellowing of the skin or eyes, dark urine, or severe stomach pain.

Hormone-sensitive conditions (e.g. breast cancer)

Because black cohosh may act like the hormone oestrogen, you should not use it if you have a history of breast cancer, uterine cancer, or endometriosis without specialist medical supervision.

Shellfish allergy

Many glucosamine supplements are made from the shells of crustaceans. If you have a shellfish allergy, you must check the label carefully as it could trigger a severe allergic reaction.

Food and drink warnings

Alcohol

Black cohosh has been linked to rare but serious cases of liver damage. Because alcohol also puts strain on the liver, it is advisable to limit or avoid alcohol consumption while taking this supplement to reduce the risk of liver toxicity.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.