magnesium transporter 1
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A MAGT1 gene provides instructions for making a protein called a magnesium transporter, which moves charged atoms (ions) of magnesium (Mg2+) into certain immune system cells called T cells. T cells recognise foreign invaders, such as viruses, bacteria, and fungi, and are then turned on (activated) to attack these invaders in order to prevent infection and illness. Specifically, the magnesium transporter produced from the MAGT1 gene is active in CD8+ T cells, which are especially important in controlling viral infections such as the Epstein-Barr virus (EBV). These cells normally take in magnesium when they detect a foreign invader, and the magnesium is involved in activating the T cell's response.
Normal function
A MAGT1 gene provides instructions for making a protein called a magnesium transporter, which moves charged atoms (ions) of magnesium (Mg2+) into certain immune system cells called T cells. T cells recognise foreign invaders, such as viruses, bacteria, and fungi, and are then turned on (activated) to attack these invaders in order to prevent infection and illness. Specifically, the magnesium transporter produced from the MAGT1 gene is active in CD8+ T cells, which are especially important in controlling viral infections such as the Epstein-Barr virus (EBV). These cells normally take in magnesium when they detect a foreign invader, and the magnesium is involved in activating the T cell's response.
Researchers suggest that magnesium transport may also be involved in the production of another type of T cell called helper T cells (CD4+ T cells) in a gland called the thymus. CD4+ T cells direct and assist the functions of the immune system by influencing the activities of other immune system cells.
Conditions referring to this gene or chromosome
Other names
bA217H1.1
DKFZp564K142
IAP
implantation-associated protein
magnesium transporter protein 1
MRX95
oligosaccharyltransferase 3 homolog B
OST3B
PRO0756
XMEN
Related patient information and medicines
Patient information leaflet
Posso tomar Ezetimiba e Magnésio juntos?
Taking magnesium (specifically as an antacid) at the same time as ezetimibe may slightly lower the amount of ezetimibe your body absorbs. Why this happens Magnesium-containing antacids can physically bind to ezetimibe in the digestive tract or change the acidity of the stomach, which slightly reduces the rate at which the medicine enters the.
Patient information leaflet
Posso tomar Esomeprazol e Magnésio juntos?
Taking esomeprazole for a long time (usually more than three months) can lower the levels of magnesium in your blood. helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take togetherDisclaimer This information is for general educational purposes only and should not be relied upon as a substitute.
Patient information leaflet
Posso tomar Black cohosh e Magnésio juntos?
Existem não known significant interactions between black cohosh and magnesium supplements. They are generally considered safe to take together. Why this happens Black cohosh and magnesium are processed by the body through different pathways. Black cohosh é primarily broken down by the liver, while magnesium is an essential mineral absorbed in.
Patient information leaflet
Posso tomar Colecalciferol e Esomeprazol juntos?
Hypercalcaemia (high blood calcium) Do not take colecalciferol if you have high levels of calcium in your blood or urine, or if you have severe kidney stones, as vitamin D increases calcium abso... Low magnesium levels (hypomagnesaemia) Taking esomeprazole for more than 3 months can cause your blood magnesium levels to drop. This is particularly.
Patient information leaflet
Posso tomar Esomeprazol e Tizanidina juntos?
Liver disease Tizanidine is primarily processed by the liver; if you have doença hepática problems, this medicine can build up to dangerous levels and cause severe side effects. Magnesium deficiency Taking e someprazole for more than three months can cause your blood magnesium levels to drop significantly, leading to fatigue, muscle spasms, or dizziness..
Patient information leaflet
Posso tomar Esomeprazol e Ezetimiba juntos?
There are no known significant interactions between esomeprazole and ezetimibe. Por que isso acontece Esomeprazole (a proton pump inhibitor) and ezetimibe (a cholesterol absorption inhibitor) work through different pathways in the body and do not significantly interfere with each other's absorption, metabolism, or excretion. What... Magnesium.
Leitura adicional e referências
- magnesium transporter 1; MedlinePlus, National Library of Medicine.
- Brandao K, Deason-Towne F, Perraud AL, Schmitz C. The role of Mg2+ in immune cells. Immunol Res. 2013 Mar;55(1-3):261-9. doi: 10.1007/s12026-012-8371-x.
- Chaigne-Delalande B, Li FY, O'Connor GM, Lukacs MJ, Jiang P, Zheng L, Shatzer A, Biancalana M, Pittaluga S, Matthews HF, Jancel TJ, Bleesing JJ, Marsh RA, Kuijpers TW, Nichols KE, Lucas CL, Nagpal S, Mehmet H, Su HC, Cohen JI, Uzel G, Lenardo MJ. Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D. Science. 2013 Jul 12;341(6142):186-91. doi: 10.1126/science.1240094.
- Li FY, Chaigne-Delalande B, Kanellopoulou C, Davis JC, Matthews HF, Douek DC, Cohen JI, Uzel G, Su HC, Lenardo MJ. Second messenger role for Mg2+ revealed by human T-cell immunodeficiency. Nature. 2011 Jul 27;475(7357):471-6. doi: 10.1038/nature10246.
- Li FY, Chaigne-Delalande B, Su H, Uzel G, Matthews H, Lenardo MJ. XMEN disease: a new primary immunodeficiency affecting Mg2+ regulation of immunity against Epstein-Barr virus. Blood. 2014 Apr 3;123(14):2148-52. doi: 10.1182/blood-2013-11-538686. Epub 2014 Feb 18.
- Li FY, Lenardo MJ, Chaigne-Delalande B. Loss of MAGT1 abrogates the Mg2+ flux required for T cell signaling and leads to a novel human primary immunodeficiency. Magnes Res. 2011 Sep;24(3):S109-14. doi: 10.1684/mrh.2011.0286.
- Wolf FI, Trapani V. MagT1: a highly specific magnesium channel with important roles beyond cellular magnesium homeostasis. Magnes Res. 2011 Sep;24(3):S86-91. doi: 10.1684/mrh.2011.0288.
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