68Ga-DOTATATE Neuroblastoma Imaging Pilot
Neuroblastoma is a common childhood cancer. Doctors use different scans to understand how far it has spread and to guide treatment. Sometimes these scans give different information, which can make it harder to decide the best treatment plan. This study is testing a new type of advanced scan, called 68Ga-DOTATATE PET/CT, in children and young adults aged up to 21 who have neuroblastoma or are suspected of having it. The main goal is to check if this new scan is safe and works well. Researchers will compare the results of the new scan with the standard 123I-MIBG scan to see if it provides clearer or more helpful information about the cancer. This information could help doctors make more accurate treatment decisions in the future.
Em resumo
Sobre o que é este estudo?
Neuroblastoma is the most common type of cancer that develops outside the brain in children. When a child is diagnosed, doctors need to know exactly where the cancer is and if it has spread. They do this using different types of scans like CT, MRI, and other special scans. However, sometimes these different scans don't always show the same picture, which can make it tricky for doctors to choose the best treatment approach.
This study is looking into a new, more advanced scanning technique called 68Ga-DOTATATE PET/CT. This scan uses a special, very small amount of a radioactive substance that helps certain types of cancer cells show up clearly on the pictures. The aim is to see if this new scan can give doctors a better and clearer view of neuroblastoma compared to the scanning method currently used, which is called 123I-MIBG. By getting clearer pictures, doctors might be able to plan treatments more effectively.
The study will involve children and young adults who have been diagnosed with neuroblastoma or are thought to have it. They will have both the standard 123I-MIBG scan and this new 68Ga-DOTATATE PET/CT scan. Researchers will then carefully compare the results from both scans to understand how helpful the new method is. The study also wants to make sure that the new scan is safe for patients.
Pontos principais
- This study is testing a new scanning method for neuroblastoma.
- It aims to see if the new scan is safe and provides clearer pictures than current methods.
- Participation involves one extra scan of about 2 hours.
- The study is for children and young adults up to 21 years old with neuroblastoma.
- Information from your medical records will be followed for up to 2 years.
Quem pode ser elegível?
This study is open to children and young adults from birth up to 21 years old who have neuroblastoma, either newly suspected or confirmed, or if their neuroblastoma has come back.
To join, you or your child must already be scheduled to have a standard 123I-MIBG scan. An adult (either the participant if they are an adult, or a parent/legal guardian for a child) must be able to understand and sign a consent form in English or French.
There are some reasons why you or your child might not be able to join. These include having had another type of cancer (other than certain non-serious skin cancers) in the last five years, currently being in another study where the treatment is unknown, or if you are currently receiving cancer treatment. Also, if there has been any surgery or treatment to the tumour between your planned 123I-MIBG scan and the new scan, you wouldn't be able to take part. Being medically unwell and unable to have the scan, or if you are pregnant, would also exclude participation. If you are breastfeeding, you would need to stop for at least 12 hours after the new scan.
Este estudo pode ser adequado para você?
Responda a estas perguntas rápidas para ver se você pode ser elegível. Este é apenas um guia — a decisão final é da equipe de pesquisa.
- Is the person with neuroblastoma aged between 1 day and 21 years?
- Do they have newly suspected neuroblastoma, a confirmed diagnosis, or has it returned?
- Are they already due to have a standard 123I-MIBG scan?
- Can an adult (the participant or a parent/guardian) understand and sign a consent form?
- Are they currently not receiving active cancer treatment?
- Have they not had another cancer diagnosis in the last 5 years (excluding certain skin cancers)?
O que envolve a participação?
If you or your child decide to take part, you will have a 68Ga-DOTATATE PET/CT scan a few days after your planned 123I-MIBG scan. This new scan will take about 2 hours to complete. During this time, a small amount of a special liquid will be given, and then the scan will take pictures. The doctors will also collect information from your existing medical records, including details about your health, any treatments you've had, and other test results. This information will be followed up for a period of up to 2 years after the scan.
Riscos e benefícios potenciais
Localizações (3)
- McGill University Health Center - Children's hospitalCódigo postal verificadoMontreal, Canadá· Retirado
- CHU Ste-JustineCódigo postal verificadoMontreal, Canadá· Recrutamento
- CIUSSS de l'Estrie-CHUS HospitalCódigo postal verificadoSherbrooke, Canada· Recrutamento
Perguntas frequentes
O que é neuroblastoma?
Neuroblastoma is a type of cancer that usually starts in nerve cells outside the brain, most often in young children.
What is the new scan, 68Ga-DOTATATE PET/CT?
It's an advanced imaging test that uses a special, very small amount of a mildly radioactive substance to help doctors see neuroblastoma cells more clearly than standard scans.
Is the new scan safe?
The study aims to check the safety of this new scan. It involves a very small amount of radiation, similar to other medical scans.
How long will I/my child be involved in the study?
You'll have one extra scan (lasting about 2 hours) a few days after a standard scan, and then your medical information will be followed up for up to 2 years.
Do I have to take part?
No, taking part is completely voluntary. Your decision will not affect your or your child's medical care.
Como saber mais
Amelie Tetu, MSc
Sempre consulte seu médico ou especialista antes de decidir participar de um estudo.
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Desenvolvido pelo nosso fórum em community.patient.info. Por favor, seja respeitoso — isto não é um conselho médico.