A Study to Evaluate the Efficacy of Cemsidomide + Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma

To join this study, you need to be at least 18 years old and have been diagnosed with multiple myeloma that has either come back or isn't responding to other treatments. You also need to have received at least three different types of anti-myeloma treatments before, including specific kinds of drugs like those that target immune cells, proteasome inhibitors, and anti-CD38 antibodies, or newer T-cell therapies, unless these weren't available in your area.

There are also some important health requirements. Your body's organs, like your heart, liver, and kidneys, need to be working well. Any side effects you had from previous cancer treatments must have cleared up or be very mild. For women, it's important not to be pregnant, plan to become pregnant, or breastfeed during the study and for a period after. Men must agree to use contraception during the study and for some time after. Also, you shouldn't have certain other health conditions like specific types of nerve problems, other cancers that are active, or a history of certain heart or blood clot issues.

Crucially, you cannot have had Cemsidomide before, as this is a new treatment being tested. The study will also check that your myeloma hasn't spread to your brain or spinal cord. These rules help make sure the study is safe for everyone involved and that the results are clear.

If you decide to take part in this study, you'll be given Cemsidomide and Dexamethasone. You'll have regular visits to the hospital or clinic for check-ups, blood tests, and to make sure the treatment is working as expected and you're not experiencing any severe side effects. The exact schedule of these visits and tests will be explained to you in detail by the study team.

During your time in the study, doctors will closely monitor your health and how your multiple myeloma responds to the treatment. This will involve various medical assessments. The overall duration of your participation in the study will depend on how you respond to the treatment and what your doctor decides, but typically involves ongoing treatment cycles followed by a period of follow-up after the treatment has finished. You will be given clear instructions on your medication, including how and when to take it.