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Ativo, mas não recrutandoFASE1INTERVENCIONISTA

A Study of Talquetamab With Other Anticancer Therapies in Participants With Multiple Myeloma

This research study is about a new drug called talquetamab, which is being tested in people who have multiple myeloma. Doctors want to see how safe talquetamab is when given along with other common cancer medicines like Carfilzomib, Daratumumab, Lenalidomide, and Pomalidomide. They are also trying to find the best and safest amounts (doses) of these drug combinations to give. This is an early-stage study (Phase 1), which means they are carefully checking for any side effects and how the body handles the new treatment combinations before moving on to larger studies.

Em resumo

Status
Ativo, mas não recrutando
Fase
FASE1
Patrocinador
Janssen Pesquisa & Desenvolvimento, LLC
Meta de inscrição
166
Iniciar
22 Sep 2021
Conclusão estimada
31 Dez 2027

Sobre o que é este estudo?

This study is investigating a new treatment approach for multiple myeloma, a type of blood cancer that affects your bone marrow. The main focus is on a new medicine called talquetamab. Researchers want to understand how safe this new drug is when it's given together with other treatments that are already used for multiple myeloma. They will be looking at different combinations of talquetamab with drugs like Carfilzomib, Daratumumab, Lenalidomide, and Pomalidomide.

The main aim is to find out which doses of these combinations are safe for people to take and to observe any side effects. This is a very important first step in developing new treatments. By finding safe doses, future studies can then focus more on how well these combinations work at fighting the cancer.

Taking part in a study like this helps doctors learn more about new medicines. This knowledge can then be used to help future patients with multiple myeloma. It's an opportunity to contribute to medical science and potentially benefit from new treatments that aren't yet widely available.

Pontos principais

  • The study is testing a new drug called talquetamab for multiple myeloma.
  • It's looking at talquetamab combined with other existing cancer treatments.
  • The main goal is to find safe doses and understand any side effects of these combinations.
  • This is an early-stage study (Phase 1) focused on safety.
  • Participants will receive close medical monitoring throughout the study.

Quem pode ser elegível?

To join this study, you must have been diagnosed with multiple myeloma and your doctors need to be able to measure your cancer – for example, through blood or urine tests. You should also generally be well enough to take part in a study, meaning you can perform most of your usual daily activities without too much difficulty.

There are some reasons why you might not be able to join. For example, if you've recently had certain vaccines or have received a high dose of steroid medicines in the past two weeks. Also, if your multiple myeloma is affecting your brain or spinal cord, or if you have certain other serious medical conditions like a history of stroke or seizures within the last six months, you wouldn't be able to participate. Women must also meet specific pregnancy prevention requirements.

Este estudo pode ser adequado para você?

Responda a estas perguntas rápidas para ver se você pode ser elegível. Este é apenas um guia — a decisão final é da equipe de pesquisa.

  1. Have I been diagnosed with multiple myeloma?
  2. Can my doctors measure my cancer in blood or urine tests?
  3. Am I generally well enough to do most of my normal daily activities?
  4. Have I had any live vaccines within the last month?
Responda a todas as perguntas para ver o seu resultado.

O que envolve a participação?

If you decide to take part in this study, you will receive talquetamab along with one of the other mentioned anticancer therapies. You'll have regular appointments at the hospital or clinic where the research team will monitor your health very closely. These appointments will involve physical exams, blood tests, and other checks to see how you are responding to the treatment and to keep an eye on any side effects.

The specific number of visits and tests will vary depending on which treatment combination you receive and how long you are on the study. The study team will explain everything in detail, including how long you are expected to receive treatment and any follow-up appointments after that. The total duration of participation will depend on how you respond to the treatment and the study plan, but detailed information will be provided before you agree to participate.

Riscos e benefícios potenciais

Taking part in a clinical study can offer potential benefits, such as access to new treatments like talquetamab that are not yet widely available. You will also receive careful medical monitoring throughout the study. However, there are also potential risks; new treatments can have side effects that are not yet fully known, and the treatment might not work for everyone. You have the right to withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Locations (31)

  • Universidade do Alabama em Birmingham
    Código postal verificado
    Birmingham, Estados Unidos
  • Universidade da Califórnia, São Francisco
    Código postal verificado
    São Francisco, Estados Unidos
  • Colorado Blood Cancer Institute
    Código postal verificado
    Denver, Estados Unidos
  • Universidade Emory
    Código postal verificado
    Atlanta, Estados Unidos
  • Indiana University
    Código postal verificado
    Indianápolis, Estados Unidos
  • Hackensack University Medical Center
    Código postal verificado
    Hackensack, Estados Unidos
  • Mt. Sinai School of Medicine
    Código postal verificado
    Nova Iorque, Estados Unidos
  • Weill Cornell Medical College
    Código postal verificado
    Nova Iorque, Estados Unidos
  • Instituto de Câncer Levine
    Código postal verificado
    Charlotte, Estados Unidos
  • University of Pittsburgh Medical Center
    Código postal verificado
    Pittsburgh, Estados Unidos
  • Tennessee Oncology
    Código postal verificado
    Nashville, Estados Unidos
  • Medical College Of Wisconsin
    Código postal verificado
    Milwaukee, United States

Perguntas frequentes

What is multiple myeloma?

Multiple myeloma is a type of cancer that affects plasma cells, which are a type of white blood cell found in the bone marrow. These cells are important for fighting infections.

What is talquetamab?

Talquetamab is a new investigational drug being studied for multiple myeloma. It's designed to help your immune system fight the cancer cells.

Why combine talquetamab with other drugs?

Doctors often combine different drugs to treat cancer. Sometimes, drugs work better together than alone, potentially leading to more effective treatment and fewer side effects.

O que significa 'Fase 1'?

Phase 1 is the first stage of human testing for a new drug. The main goal at this stage is to check if the treatment is safe and to find the best dose, rather than how effective it is yet.

Will I get to choose which combination therapy I receive?

In early phase studies like this, the study doctors typically decide which combination you will receive based on the study design and your medical background.

Como saber mais

Sempre consulte seu médico ou especialista antes de decidir participar de um estudo.

Discussão

Discussão da comunidade

Desenvolvido pelo nosso fórum em community.patient.info. Por favor, seja respeitoso — isto não é um conselho médico.