A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1982 to Prevent Lyme Disease in Healthy Participants (18 to 70 Years of Age)

To join this study, you need to be a healthy adult between 18 and 70 years old. A doctor will check your overall health to make sure you are suitable. If you could become pregnant, you'll need to use reliable birth control methods during the study.

However, there are some reasons why you might not be able to take part. For example, if you've ever had a very serious allergic reaction to any mRNA vaccine or its ingredients, this study wouldn't be right for you. Also, if you currently have Lyme disease, or have had it treated in the last three months, or have a long-term illness linked to Lyme disease, you wouldn't be able to join.

If you've already had a Lyme disease vaccine before, or if you had a tick bite very recently (within four weeks before the study starts), you also wouldn't be eligible. The study team will go through all these details with you carefully to see if you can take part.

Taking part in this study would involve several visits to a clinic over a period of time. You would receive either the new mRNA-1982 vaccine or a placebo (a dummy injection) – you wouldn't know which one you received. During your visits, doctors and nurses would check your health, ask about any side effects, and take blood samples to see how your body is responding to the vaccine or placebo. You would be closely monitored throughout the study to track your health and any reactions. The total duration of your involvement in the study would be explained to you in detail by the study team.