Microbiome in Atopic Dermatitis Under Systemic Therapy
This research study is for people in the UK with moderate to severe eczema (atopic dermatitis) who are starting a new type of treatment from their doctor, like a biologic or a JAK inhibitor. We want to understand how these new medicines affect the tiny living things (microbiome) on your skin. Scientists aren't sure if these changes cause eczema or happen because of it. By studying this, we hope to learn more about eczema itself and develop better ways to measure its severity and find new treatments. You would attend routine check-ups, and we'd take some blood and skin swab samples, which wouldn't involve any extra visits or painful procedures beyond your usual care.
Em resumo
Sobre o que é este estudo?
This study is all about understanding eczema better, especially how new medicines for moderate to severe eczema affect the skin. Scientists are interested in the 'microbiome' – that's all the tiny living things, like bacteria, that naturally live on your skin. They want to find out if changes in these tiny living things cause eczema, or if eczema makes them change. It's a bit like trying to figure out if chickens came before eggs!
New medicines for eczema, such as biologics or JAK inhibitors, are becoming more common. This study aims to see if and how these new treatments affect the skin's microbiome. By learning more about these connections, we hope to develop new ideas about what causes eczema. This could also help doctors measure how severe your eczema is more accurately and, in the long run, lead to better, more targeted treatments for everyone with eczema.
Being part of this study means you'd be helping scientists gain a deeper understanding of this common skin condition. The information we gather could pave the way for future improvements in how eczema is managed and treated.
Pontos principais
- This study helps understand how new eczema medicines affect skin bacteria.
- It's for adults with moderate to severe eczema starting new systemic treatments.
- Participation involves routine visits, blood tests, and a small skin swab.
- No extra appointments or experimental medications are involved beyond your usual care.
- Your contribution could lead to better eczema treatments in the future.
- Você pode parar de participar a qualquer momento sem afetar seu atendimento médico.
Quem pode ser elegível?
To join this study, you need to be an adult (18 years or older) who has moderate to severe eczema. This means your doctor has decided that you need a stronger type of treatment, often called a 'systemic therapy', to help manage your eczema.
There are a few reasons why you wouldn't be able to join. If you are under 18 when you start this new treatment, or if you are pregnant or breastfeeding, then this study isn't suitable for you. The study is designed for adults who are starting a specific type of eczema medication.
Este estudo pode ser adequado para você?
Responda a estas perguntas rápidas para ver se você pode ser elegível. Este é apenas um guia — a decisão final é da equipe de pesquisa.
- Tenho 18 anos ou mais.
- I have moderate to severe eczema.
- My doctor is planning to start me on a new 'systemic therapy' for my eczema.
- I am not pregnant or breastfeeding.
O que envolve a participação?
If you decide to take part, you'll be part of an 'observational study'. This means we'll be watching and learning from your journey without giving you any experimental medication. You won't need extra visits to the clinic; everything will happen during your usual routine check-ups with your doctor, which are typically every three months over two years. The key times for the study are before you start your new medication, and then at 6, 12, and 24 months after you start. If you begin a new treatment, we'll also invite you for a check-up six weeks later.
During these visits, we'll take a small blood sample. This is to check for certain markers in your blood related to inflammation and to look at your genes, which might give clues about your eczema. We'll also take a skin swab from your upper back (between your shoulder blades) to collect samples of your skin microbiome. This is a very quick and painless procedure. Your blood and skin samples will be given a code to protect your privacy and stored for up to five years after the study ends before being safely destroyed.
Riscos e benefícios potenciais
Localizações (1)
- Dpt of Dermatology and Allergology, Charité - Universitätsmedizin BerlinCódigo postal verificadoBerlim, Alemanha· Recrutamento
Perguntas frequentes
What is the 'microbiome'?
The microbiome is made up of all the tiny living things, like bacteria, that naturally live on and inside your body, including your skin.
What does 'systemic therapy' mean?
Systemic therapy refers to medicines that work throughout your whole body, rather than just on the skin's surface, like creams. Examples include biologics or JAK inhibitors for eczema.
Will I have to take any new medicines as part of this study?
No, this is an observational study. You will continue to take the eczema medication prescribed by your doctor, but you won't be given any experimental medicines for the study itself.
Por quanto tempo estarei envolvido no estudo?
Your involvement in the study will last for two years, aligning with your routine check-up visits every three months.
Minhas informações serão mantidas privadas?
Yes, all your blood and skin samples will be given a code (pseudonymised) so your personal details are not directly linked to the samples. Your privacy is very important.
Como saber mais
Margitta Worm, Prof
Sempre consulte seu médico ou especialista antes de decidir participar de um estudo.
Interessado em participar?
Discussão
Discussão da comunidade
Desenvolvido pelo nosso fórum em community.patient.info. Por favor, seja respeitoso — isto não é um conselho médico.