Rifabutina para infecção
Mycobutin
Revisado por Sid DajaniÚltima atualização por Michael Stewart, MRPharmSÚltima atualização 19 Nov 2024
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Rifabutin is an antibiotic which is used to treat (or prevent) serious infections caused by germs (bacteria) called mycobacteria.
You can take rifabutin capsules either before or after meals. You will be asked to take one dose a day.
Rifabutin can interfere with a number of other medicines - please let your doctor know which other medicines you are taking.
Em resumo
Rifabutin is an antibiotic used to treat or prevent serious infections caused by mycobacteria, including tuberculosis.
Dosage varies depending on why it is prescribed, but you must complete the full course.
Rifabutin can cause urine, sweat, or skin to turn orange-red, which is harmless.
It can reduce the effectiveness of some hormonal contraceptives.
Rare but serious side effects include severe diarrhoea, persistent sickness, or jaundice.
About rifabutin
Tipo de medicamento | An antibiotic and antituberculosis medicine |
Usado para | To treat infections caused by mycobacteria, especially in people with low immunity |
Também chamado de | Mycobutin® |
Disponível como | Cápsulas |
Mycobacteria are a group of germs (bacteria) that can cause serious infections. Tuberculose (TB) is a disease caused by one of the bacteria from this group, called Mycobacterium tuberculosis. TB usually affects the lungs.
Rifabutin is an antibiotic used to treat infections caused by mycobacteria. It is often prescribed for people with pulmonary TB. When prescribed in this way, it is usually prescribed as just one of a number of medicines to treat the infection. You may have been prescribed it for this reason. Alternatively, if your doctor thinks you might be at risk of a mycobacterial infection because your natural immunity has been lowered (such as if you have HIV), you will have been prescribed rifabutin as a preventative measure, to protect you from getting a mycobacterial infection.
Before taking rifabutin
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking rifabutin it is important that your doctor knows:
Se você está grávida, tentando ter um bebê ou amamentando.
If you have any problems with how your liver works, or any problems with the way your kidneys work.
If you have a rare inherited blood disorder caller porphyria.
Se você estiver tomando outros medicamentos. Isso inclui quaisquer medicamentos que você esteja tomando e que estejam disponíveis para compra sem receita médica, bem como medicamentos fitoterápicos e complementares.
Se você já teve uma reação alérgica a um medicamento.
How to take rifabutin
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about rifabutin and will provide you with a full list of the side-effects which you could experience from taking it.
There are several ways rifabutin could be prescribed for you, depending upon the reason why you are taking it. Your doctor will tell you which way is right for you. It is very important that you take rifabutin exactly as your doctor tells you to. Your dose will be printed on the label of the pack to remind you about what the doctor said to you. As a guide:
To prevent infections, you will be asked to take two capsules every day.
To treat TB you will be asked to take one to three capsules every day.
To treat an infection (other than TB) you will be asked to take three or four capsules every day.
You can take rifabutin at whatever time of day you find easiest to remember, but try to take your doses at the same time of day, each day. This will help you to remember to take your doses regularly. You can take rifabutin capsules either before or after meals.
If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, leave out the forgotten dose from the previous day and take the dose that is due as normal. Do not take two doses together to make up for a missed dose.
You must complete the full course of treatment (unless your doctor tells you otherwise) or your infection may come back. A course of treatment usually lasts for around six months. If you are taking rifabutin to prevent an infection, it is likely that you will be asked to take the capsules for the rest of your life.
Obtendo o máximo do seu tratamento
It is important that you keep your regular appointments with your doctor. This is so your doctor can check on your progress. Your doctor may want you to have some blood tests from time to time during the treatment to make sure that your blood and liver are working properly.
Rifabutin can cause your urine, sweat or skin to have an orange-reddish colour. This is completely harmless - it is nothing for you to worry about.
If you wear soft contact lenses, please be aware that rifabutin can cause your lenses to become discoloured or stained. You may want to discuss this with your doctor or optician. An alternative type of contact lens may be more suitable for you, or alternatively, you may be advised to wear glasses instead.
Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. The contraceptive effect of 'the pill', 'mini pill', contraceptive patches and vaginal rings is reduced by rifabutin and so these on their own are not suitable types of birth control.
If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because rifabutin can interfere with a number of other medicines and stop them from working properly.
Rifabutin can stop the oral typhoid vaccine from working as it should. If you are due to have any vaccinations, please make sure that the person treating you knows that you are taking this medicine.
If you are due to have an operation or any dental treatment, please tell the person carrying out the treatment that you are taking an antibiotic called rifabutin.
Can rifabutin cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with rifabutin. You will find a full list in the manufacturer's information leaflet supplied with the medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common rifabutin side-effects (these affect fewer than 1 in 10 people) | O que posso fazer se passar por isso? |
Sentindo-se enjoado (náusea) | Mantenha refeições simples ou sem sabor (evite alimentos ricos e condimentados) |
Muscle pain, high temperature (fever), and rash | Se algum desses se tornar problemático, fale com seu médico para obter aconselhamento |
Changes to some blood test results (you may get frequent infections, or feel very tired) | Seu médico verificará estes |
Importante: if you develop severe diarrhoea, persistent sickness (vomiting), or any yellowing of your skin or the whites of your eyes (jaundice), you should speak with a doctor imediatamente. These are rare but serious side-effects that you must tell your doctor about as soon as possible.
Se você sentir quaisquer outros sintomas que acha que podem ser devido ao medicamento, por favor, fale com seu médico ou farmacêutico para mais orientações.
How to store rifabutin
Mantenha todos os medicamentos fora do alcance e da vista das crianças.
Armazene em local fresco e seco, longe de calor e luz diretos.
Informações importantes sobre todos os medicamentos
Informações importantes sobre todos os medicamentos
Não tome mais do que a dose prescrita. Se você suspeitar que você ou outra pessoa tomou uma overdose deste medicamento, vá ao pronto-socorro do hospital mais próximo. Leve o recipiente com você, mesmo que esteja vazio.
Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.
Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.
Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.
Relatar efeitos colaterais de um medicamento ou vacina
Se você sentir efeitos colaterais, pode relatá-los online através do Site do Yellow Card.

Inseguro sobre misturar medicamentos?
Verifique possíveis interações entre medicamentos, suplementos e alimentos antes de tomá-los juntos.
Perguntas frequentes
What is the typical duration of rifabutin treatment?
If you are taking rifabutin to treat an infection, a course of treatment usually lasts for around six months. However, if you are prescribed rifabutin to prevent an infection, it's likely you will need to take the capsules for the rest of your life.
Can rifabutin affect my vision or eyes?
Yes, rifabutin can cause your urine, sweat, or skin to have an orange-reddish colour, and this can also discolour or stain soft contact lenses. You may need to discuss alternative contact lenses with your doctor or optician, or consider wearing glasses instead.
Are there any specific foods or drinks I should avoid while taking rifabutin?
If you experience feeling sick (nausea) as a side-effect, it is recommended to stick to simple or bland meals and avoid rich and spicy foods to help manage this.
What should I do if rifabutin makes me feel very unwell with muscle pain, fever, or a rash?
Muscle pain, high temperature (fever), and rash are common side-effects. If any of these become troublesome, you should speak with your doctor for advice.
Can rifabutin interact with over-the-counter medicines or herbal remedies?
Yes, it's important to tell your doctor about all medicines you are taking, including those bought without a prescription, as well as herbal and complementary medicines. Rifabutin can interfere with other medicines and stop them from working properly, so always check with a pharmacist if buying new medicines.
Leitura adicional e referências
- Manufacturer's PIL, Mycobutin®; Pfizer Limited, The electronic Medicines Compendium. Dated August 2023.
- Medicamentos Completo BNF 89ª Edição; Associação Médica Britânica e Sociedade Real de Farmácia da Grã-Bretanha, Londres.
Sobre o autorVer biografia completa

Michael Stewart, MRPharmS
Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico
BPharm (Hons), MRPharmS
Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.
Sobre o revisor

Sid Dajani
Sultan Dajani se formou na Escola de Farmácia de Londres em 1994 e se tornou o membro mais jovem eleito para o conselho da Sociedade Real de Farmácia desde sua fundação em 1842.
Histórico do artigo
As informações nesta página são escritas e revisadas por clínicos qualificados.
Artigo também disponível em Inglês, Alemão, Espanhol, Francês, Italiano, Português, Hindi, Hebraico, Árabe, e Sueco.
Próxima revisão prevista para: 28 Nov 2027
19 Nov 2024 | Última versão

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