Linezolid para infecção
Zyvox
Revisado por Sid DajaniÚltima atualização por Michael Stewart, MRPharmSLast updated 29 de maio de 2023
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Linezolid is an antibiotic which is given for serious infections. It will be prescribed by a specialist doctor.
The dose is 600 mg every 12 hours. This will be as an injection, or as a tablet or liquid medicine.
While you are taking linezolid, try to avoid eating mature cheese, yeast extracts (eg, Marmite®, Bovril®) or soya bean products such as soy sauce. These foods interact with linezolid and cause unpleasant symptoms.
At a glance
Linezolid is an antibiotic used for serious infections that are hard to treat.
It treats pneumonia and skin infections caused by MRSA bacteria.
You must tell your doctor about all other medicines you are taking.
Take doses 12 hours apart, usually morning and evening.
Avoid foods high in tyramine, such as mature cheese, and alcohol while taking this medicine.
You will need weekly blood tests during treatment.
See your doctor immediately if you have vision changes or a throbbing headache after eating.
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About linezolid
Tipo de medicamento | An oxazolidinone antibiotic |
Usado para | Treatment of pneumonia; difficult-to-treat skin infections |
Também chamado de | Zyvox® |
Disponível como | Tablets, oral liquid medicine, and injection |
Linezolid is an antibiotic which is used for serious infections which are difficult to treat with other antibiotics.
It is used to treat pneumonia, which is a serious lung infection. It is also used to treat skin and soft tissue infections caused by infection with MRSA bacteria. These types of bacteria are resistant to treatment with many other antibiotics. Treatment is started in hospital, often as an injection given directly into a vein. As your treatment progresses, you may be given tablets or liquid medicine to take instead of having injections.
Before taking linezolid
Voltar ao conteúdoSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start linezolid it is important that your doctor knows:
If you are taking any other medicines. It is muito important that you tell your doctor about todas the medicines that have been prescribed for you, as well as any medicines that you have bought without a prescription or herbal and complementary medicines. This is because linezolid must not be taken at the same time as some other medicines. These include some medicines for depression, 'triptans' for migraine, some painkillers, and decongestant medicines which are often included in cold and flu remedies.
Se você está grávida ou amamentando.
If you have any problems with the way your liver works, or the way your kidneys work.
Se você tem pressão alta (hipertensão).
Se você tem uma glândula tireoide hiperativa.
Se você já teve uma convulsão (ataque epiléptico).
If you have schizophrenia or bipolar depression.
If you have been told you have a carcinoid tumour (a rare tumour of the hormone system), or a tumour on your adrenal glands, called phaeochromocytoma.
Se você já teve uma reação alérgica a um medicamento.
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How to take linezolid
Voltar ao conteúdoAsk to read the manufacturer's printed information leaflet. It will give you more information about linezolid and will provide a full list of the side-effects which you may experience from taking it. Your doctor may also give you some additional printed information - it is important that you read all the information you are given.
Take linezolid exactly as your doctor tells you to. You will be asked to take two doses each day, 12 hours apart. This will usually mean taking a dose each morning and evening. You can take linezolid before or after meals.
If you have been given the oral liquid medicine, do not shake the bottle. Instead, turn the bottle upside down a few times before you remove the lid and pour out your dose.
Try to remember to take your doses at the correct times, and not to miss any. If you do forget to take a dose, take it as soon as you remember and then take the next dose 12 hours afterwards. Continue to take a dose every 12 hours. Do not take two doses together to make up for a forgotten dose.
It is usual for a course of treatment to last for 10-14 days. Even if you feel your infection has cleared up, keep taking the antibiotic until the course has finished (unless your doctor tells you otherwise). This is to prevent the infection from coming back and being more difficult to treat.
Obtendo o máximo do seu tratamento
Voltar ao conteúdoLinezolid can react with a substance called tyramine which is contained in foods such as mature cheese, yeast extracts (eg, Marmite®, Bovril®), and soya bean products (eg, soy sauce). While you are taking linezolid, avoid eating any of these, as they will cause an increase in your blood pressure. Also, avoid drinking alcohol, especially draught beers.
Keep the scheduled appointments with your doctor so that your progress can be monitored. You will need to have a blood test each week while you are taking this antibiotic.
Some people develop thrush (redness and itchiness in the mouth or vagina) after taking a course of antibiotics. If this happens to you, speak with your doctor or pharmacist for advice.
Do not buy or take any medicines without checking first with your doctor or a pharmacist that they are suitable for you to take with this antibiotic.
If you are due to have any other medical treatment, tell the person carrying out the treatment that you are taking this antibiotic.
Este antibiótico pode impedir que a vacina oral contra a febre tifoide funcione. Se você estiver prestes a tomar alguma vacina, certifique-se de que a pessoa que está tratando você saiba que está tomando este medicamento.
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Can linezolid cause problems?
Voltar ao conteúdoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with linezolid. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common linezolid side-effects (these affect fewer than 1 in 10 people) | O que posso fazer se passar por isso? |
Dor de cabeça | If the headache is severe and occurs after eating food, speak with your doctor straightaway |
Diarreia | Drink plenty of water to replace lost fluids. If the diarrhoea is severe, speak with your doctor straightaway |
Sentindo-se mal (náusea) ou vomitando (vômito) | Mantenha-se em refeições simples - evite alimentos ricos ou picantes |
Metallic taste in the mouth | Try taking your doses with some food or a drink to take away the taste |
Alterações em alguns exames de sangue | Your doctor will ask you to have regular blood tests to check for this |
Importante: your doctor will discuss with you the possibility of some less common side-effects occurring. You must let your doctor know straightaway about the following:
Any changes in your eyesight, such as blurred vision or colour changes.
If you develop a throbbing headache after eating or drinking something.
Se você sentir quaisquer outros sintomas que acha que podem ser devido ao medicamento, fale com seu médico ou farmacêutico para obter aconselhamento.
How to store linezolid
Voltar ao conteúdoMantenha todos os medicamentos fora do alcance e da vista das crianças.
Armazene em local fresco e seco, longe de calor e luz diretos.
If you have been given liquid medicine, it will have been made up by the pharmacy and it lasts for a limited number of days only. Check the expiry date on the bottle and do not use it after this date.
Informações importantes sobre todos os medicamentos
Voltar ao conteúdoInformações importantes sobre todos os medicamentos
Nunca tome mais do que a dose prescrita. Se suspeitar que você ou outra pessoa possa ter tomado uma overdose deste medicamento, vá ao departamento de acidentes e emergências do hospital local. Leve o recipiente com você, mesmo que esteja vazio.
Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.
Se você for se submeter a uma operação ou a qualquer tratamento dentário, informe à pessoa que está realizando o tratamento quais medicamentos você está tomando.
Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.
Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.
MHRA - Relatando reações adversas
Relate efeitos colaterais suspeitos de medicamentos, vacinas, cigarros eletrônicos, incidentes com dispositivos médicos, produtos defeituosos ou falsificados (falsos) à Agência Reguladora de Medicamentos e Produtos de Saúde para garantir o uso seguro e eficaz.

Inseguro sobre misturar medicamentos?
Verifique possíveis interações entre medicamentos, suplementos e alimentos antes de tomá-los juntos.
Perguntas frequentes
What kind of infections is Linezolid typically prescribed for?
Linezolid is an antibiotic used for serious infections that are hard to treat with other antibiotics. Specifically, it's used for pneumonia, which is a serious lung infection, and skin and soft tissue infections caused by MRSA bacteria. MRSA is known for being resistant to many other antibiotic treatments.
Is it normal to start Linezolid treatment in hospital?
Yes, treatment with linezolid often begins in a hospital setting. It is commonly given as an injection directly into a vein. As your treatment progresses, you may transition to taking it as tablets or a liquid medicine.
How long will I usually need to take Linezolid?
A typical course of linezolid treatment usually lasts between 10 to 14 days. It's important to complete the entire course of antibiotics, even if you start feeling better, unless your doctor advises you otherwise. This helps prevent the infection from returning and becoming harder to treat.
What foods or drinks should I avoid while taking Linezolid?
You should avoid foods containing tyramine, such as mature cheese, yeast extracts (like Marmite® or Bovril®), and soya bean products (like soy sauce). Eating these can increase your blood pressure while on linezolid. It's also advised to avoid drinking alcohol, especially draught beers.
Why do I need weekly blood tests while on Linezolid?
Regular blood tests are necessary each week while you are taking linezolid. This is because linezolid can cause changes to some blood test results, and your doctor will monitor these to ensure your safety and the effectiveness of the treatment.
What should I do if I notice changes to my eyesight while taking Linezolid?
It is important to tell your doctor straightaway if you experience any changes in your eyesight, such as blurred vision or changes in colour perception. These are less common but important side-effects that need immediate medical attention.
Can Linezolid affect other medications I'm taking, including over-the-counter or herbal remedies?
Yes, it's crucial to inform your doctor about all medicines you are taking, including prescribed ones, those bought without a prescription, and any herbal or complementary medicines. Linezolid must not be taken with certain other medications, such as some antidepressants, 'triptans' for migraine, specific painkillers, and decongestants found in cold and flu remedies.
Leitura adicional e referências
- Manufacturer's PIL, Zyvox® 600 mg Film-coated Tablets; Pfizer Limited, The electronic Medicines Compendium. Dated October 2020.
- Manufacturer's PIL, Zyvox® 100 mg/5 ml Granules for Oral Suspension; Pfizer Limited, The electronic Medicines Compendium. Dated November 2019.
- Medicamentos Completo BNF 89ª Edição; Associação Médica Britânica e Sociedade Real de Farmácia da Grã-Bretanha, Londres.
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About the authorView full bio

Michael Stewart, MRPharmS
Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico
BPharm (Hons), MRPharmS
Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Histórico do artigo
As informações nesta página são escritas e revisadas por clínicos qualificados.
Próxima revisão prevista para: 28 Nov 2027
29 de maio de 2023 | Última versão

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