Linezolid para infecção
Zyvox
Revisado por Sid DajaniÚltima atualização por Michael Stewart, MRPharmSÚltima atualização 29 de maio de 2023
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Linezolid is an antibiotic which is given for serious infections. It will be prescribed by a specialist doctor.
The dose is 600 mg every 12 hours. This will be as an injection, or as a tablet or liquid medicine.
While you are taking linezolid, try to avoid eating mature cheese, yeast extracts (eg, Marmite®, Bovril®) or soya bean products such as soy sauce. These foods interact with linezolid and cause unpleasant symptoms.
Em resumo
Linezolid is an antibiotic used for serious, difficult-to-treat infections.
It treats pneumonia and skin infections, including those caused by MRSA.
It can be given as an injection, tablets, or oral liquid medicine.
You will usually take two doses a day, 12 hours apart, for 10-14 days.
Avoid foods high in tyramine and limit alcohol while taking linezolid.
Tell your doctor if you experience changes in eyesight or a severe headache after eating.
About linezolid
Tipo de medicamento | An oxazolidinone antibiotic |
Usado para | Treatment of pneumonia; difficult-to-treat skin infections |
Também chamado de | Zyvox® |
Disponível como | Tablets, oral liquid medicine, and injection |
Linezolid is an antibiotic which is used for serious infections which are difficult to treat with other antibiotics.
It is used to treat pneumonia, which is a serious lung infection. It is also used to treat skin and soft tissue infections caused by infection with MRSA bacteria. These types of bacteria are resistant to treatment with many other antibiotics. Treatment is started in hospital, often as an injection given directly into a vein. As your treatment progresses, you may be given tablets or liquid medicine to take instead of having injections.
Before taking linezolid
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start linezolid it is important that your doctor knows:
If you are taking any other medicines. It is muito important that you tell your doctor about todas the medicines that have been prescribed for you, as well as any medicines that you have bought without a prescription or herbal and complementary medicines. This is because linezolid must not be taken at the same time as some other medicines. These include some medicines for depression, 'triptans' for migraine, some painkillers, and decongestant medicines which are often included in cold and flu remedies.
Se você está grávida ou amamentando.
If you have any problems with the way your liver works, or the way your kidneys work.
Se você tem pressão alta (hipertensão).
Se você tem uma glândula tireoide hiperativa.
Se você já teve uma convulsão (ataque epiléptico).
If you have schizophrenia or bipolar depression.
If you have been told you have a carcinoid tumour (a rare tumour of the hormone system), or a tumour on your adrenal glands, called phaeochromocytoma.
Se você já teve uma reação alérgica a um medicamento.
How to take linezolid
Ask to read the manufacturer's printed information leaflet. It will give you more information about linezolid and will provide a full list of the side-effects which you may experience from taking it. Your doctor may also give you some additional printed information - it is important that you read all the information you are given.
Take linezolid exactly as your doctor tells you to. You will be asked to take two doses each day, 12 hours apart. This will usually mean taking a dose each morning and evening. You can take linezolid before or after meals.
If you have been given the oral liquid medicine, do not shake the bottle. Instead, turn the bottle upside down a few times before you remove the lid and pour out your dose.
Try to remember to take your doses at the correct times, and not to miss any. If you do forget to take a dose, take it as soon as you remember and then take the next dose 12 hours afterwards. Continue to take a dose every 12 hours. Do not take two doses together to make up for a forgotten dose.
It is usual for a course of treatment to last for 10-14 days. Even if you feel your infection has cleared up, keep taking the antibiotic until the course has finished (unless your doctor tells you otherwise). This is to prevent the infection from coming back and being more difficult to treat.
Obtendo o máximo do seu tratamento
Linezolid can react with a substance called tyramine which is contained in foods such as mature cheese, yeast extracts (eg, Marmite®, Bovril®), and soya bean products (eg, soy sauce). While you are taking linezolid, avoid eating any of these, as they will cause an increase in your blood pressure. Also, avoid drinking alcohol, especially draught beers.
Keep the scheduled appointments with your doctor so that your progress can be monitored. You will need to have a blood test each week while you are taking this antibiotic.
Some people develop thrush (redness and itchiness in the mouth or vagina) after taking a course of antibiotics. If this happens to you, speak with your doctor or pharmacist for advice.
Do not buy or take any medicines without checking first with your doctor or a pharmacist that they are suitable for you to take with this antibiotic.
If you are due to have any other medical treatment, tell the person carrying out the treatment that you are taking this antibiotic.
Este antibiótico pode impedir que a vacina oral contra a febre tifoide funcione. Se você estiver prestes a tomar alguma vacina, certifique-se de que a pessoa que está tratando você saiba que está tomando este medicamento.
Can linezolid cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with linezolid. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Comum linezolid side-effects (these affect fewer than 1 in 10 people) | O que posso fazer se passar por isso? |
Dor de cabeça | If the headache is severe and occurs after eating food, speak with your doctor straightaway |
Diarreia | Drink plenty of water to replace lost fluids. If the diarrhoea is severe, speak with your doctor straightaway |
Sentindo-se mal (náusea) ou vomitando (vômito) | Mantenha-se em refeições simples - evite alimentos ricos ou picantes |
Metallic taste in the mouth | Try taking your doses with some food or a drink to take away the taste |
Alterações em alguns exames de sangue | Seu médico pedirá que você faça exames de sangue regulares para verificar isso |
Importante: your doctor will discuss with you the possibility of some less common side-effects occurring. You must let your doctor know straightaway about the following:
Any changes in your eyesight, such as blurred vision or colour changes.
If you develop a throbbing headache after eating or drinking something.
Se você sentir quaisquer outros sintomas que acha que podem ser devido ao medicamento, fale com seu médico ou farmacêutico para obter aconselhamento.
How to store linezolid
Mantenha todos os medicamentos fora do alcance e da vista das crianças.
Armazene em local fresco e seco, longe de calor e luz diretos.
If you have been given liquid medicine, it will have been made up by the pharmacy and it lasts for a limited number of days only. Check the expiry date on the bottle and do not use it after this date.
Informações importantes sobre todos os medicamentos
Informações importantes sobre todos os medicamentos
Nunca tome mais do que a dose prescrita. Se suspeitar que você ou outra pessoa possa ter tomado uma overdose deste medicamento, vá ao departamento de acidentes e emergências do hospital local. Leve o recipiente com você, mesmo que esteja vazio.
Este medicamento é para você. Nunca o dê a outras pessoas, mesmo que a condição delas pareça ser a mesma que a sua.
Se você for se submeter a uma operação ou a qualquer tratamento dentário, informe à pessoa que está realizando o tratamento quais medicamentos você está tomando.
Não guarde medicamentos vencidos ou indesejados. Leve-os à sua farmácia local, que se encarregará de descartá-los para você.
Se você tiver alguma dúvida sobre este medicamento, pergunte ao seu farmacêutico.
MHRA - Relatando reações adversas
Relate efeitos colaterais suspeitos de medicamentos, vacinas, cigarros eletrônicos, incidentes com dispositivos médicos, produtos defeituosos ou falsificados (falsos) à Agência Reguladora de Medicamentos e Produtos de Saúde para garantir o uso seguro e eficaz.

Inseguro sobre misturar medicamentos?
Verifique possíveis interações entre medicamentos, suplementos e alimentos antes de tomá-los juntos.
Perguntas frequentes
What is linezolid 600 mg used for?
Linezolid is an antibiotic prescribed for serious infections that are resistant to other treatments. Specifically, linezolid is used to treat pneumonia, a severe lung infection, and skin and soft tissue infections, especially those caused by MRSA bacteria. These infections are often difficult to treat because MRSA is resistant to many other antibiotics.
How long will I be taking linezolid?
Typically, a course of linezolid treatment lasts for 10-14 days. It's important to complete the full course of antibiotics as prescribed by your doctor, even if your infection symptoms improve or clear up before the course is finished. This helps prevent the infection from returning and potentially becoming harder to treat.
What foods should I avoid when taking linezolid?
When you are taking linezolid, you should avoid foods that contain a substance called tyramine. Examples include mature cheese, yeast extracts (like Marmite or Bovril), and soy bean products (like soy sauce). Consuming these foods can cause an increase in your blood pressure. You should also avoid drinking alcohol, especially draught beers, during treatment.
Why do I need weekly blood tests while on linezolid?
You will need to have a blood test each week while taking linezolid because this antibiotic can cause changes to some blood test results. Your doctor will monitor these changes to ensure the treatment is suitable for you and to check for any potential issues.
Can linezolid affect my eyesight?
Linezolid can, in some less common cases, cause changes in eyesight, such as blurred vision or alterations in colour perception. It is very important to inform your doctor straightaway if you notice any changes in your eyesight while taking this medicine.
What should I do if I get thrush after taking linezolid?
Some people can develop thrush, which causes redness and itchiness in the mouth or vagina, after taking a course of antibiotics. If you experience thrush while on linezolid, you should speak with your doctor or pharmacist for advice on how to manage it.
Leitura adicional e referências
- Manufacturer's PIL, Zyvox® 600 mg Film-coated Tablets; Pfizer Limited, The electronic Medicines Compendium. Dated October 2020.
- Manufacturer's PIL, Zyvox® 100 mg/5 ml Granules for Oral Suspension; Pfizer Limited, The electronic Medicines Compendium. Dated November 2019.
- Medicamentos Completo BNF 89ª Edição; Associação Médica Britânica e Sociedade Real de Farmácia da Grã-Bretanha, Londres.
Sobre o autorVer biografia completa

Michael Stewart, MRPharmS
Gerente de Revisão de Folhetos de Medicamentos – Contratado, Farmacêutico
BPharm (Hons), MRPharmS
Michael é um farmacêutico comunitário atuando nas Midlands e em South Yorkshire, com mais de 20 anos de experiência em aconselhamento sobre medicamentos e condições médicas. Ele tem uma sólida formação em treinamento em saúde, tendo produzido e ministrado cursos de treinamento para equipes de farmácia e funcionários de ambientes de cuidados residenciais, incluindo enfermeiros. Ele também contribuiu para conselhos consultivos de farmácia para o manejo de condições de baixa gravidade na comunidade.
Sobre o revisor

Sid Dajani
Sultan Dajani se formou na Escola de Farmácia de Londres em 1994 e se tornou o membro mais jovem eleito para o conselho da Sociedade Real de Farmácia desde sua fundação em 1842.
Histórico do artigo
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Próxima revisão prevista para: 28 Nov 2027
29 de maio de 2023 | Última versão

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