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Can I take Ibuprofen and Zinc together?

Drug interaction guide

Taking ibuprofen and zinc together may slightly reduce how much zinc your body absorbs. It can also increase the risk of stomach irritation or discomfort.

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Why this happens

Ibuprofen can irritate the lining of the stomach, and zinc supplements (especially on an empty stomach) are known to cause nausea or gastric upset. Additionally, some studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can interfere with the transport and absorption of zinc in the digestive tract.

It is generally safe to take these together, but to avoid stomach upset, take both with food. If you are taking high doses of zinc for a specific medical reason, you may wish to space them two hours apart to ensure you get the full benefit of the supplement.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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