Can I take Evening primrose oil and Red vine leaf extract together?
Drug interaction guide
Originally published 14 Mar 2026
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Both evening primrose oil and red vine leaf extract can thin the blood. Taking them together might increase the risk of bruising or bleeding more easily than usual.
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Why this happens
Evening primrose oil contains gamma-linolenic acid (GLA), which has mild anti-platelet effects (it makes blood cells less sticky). Red vine leaf extract contains flavonoids that improve blood flow and may also have mild blood-thinning properties. When combined, these effects can add up.
What you should do
Back to contentsThis combination is usually fine for most healthy people, but you should use caution. If you notice unusual bruising, nosebleeds, or bleeding gums, stop taking them and speak to your pharmacist. You should stop taking both supplements at least two weeks before any planned surgery. If you are already taking prescribed blood thinners (like warfarin or aspirin), do not take this combination without consulting your doctor first.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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