Can I take Entresto and Flecainide together?
Drug interaction guide
Originally published 12 May 2026
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Taking Entresto and flecainide together can increase the risk of heart rhythm problems and may cause your blood pressure to drop too low. Both medications affect how your heart beats and how your kidneys handle minerals like potassium, which can lead to an unstable heart rate.
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Why this happens
Entresto is a combination of sacubitril and valsartan. Valsartan can increase potassium levels in the blood. Flecainide is very sensitive to potassium levels; if potassium becomes too high or too low, flecainide can become toxic or stop working correctly, potentially causing dangerous heart rhythms. Additionally, both drugs can lower blood pressure, leading to an additive effect that might cause dizziness or fainting.
What you should do
Back to contentsYou must speak to your doctor before taking these together. If prescribed both, your doctor will likely perform regular blood tests to check your kidney function and potassium levels. They may also perform an ECG (heart trace) to monitor your heart rhythm. Seek medical help immediately if you feel dizzy, faint, or notice a fluttering or irregular heartbeat.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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