Can I take Dextroamphetamine and Fluvoxamine together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking these two medicines together can increase the risk of a rare but serious condition called serotonin syndrome. It can also lead to higher levels of dextroamphetamine in your blood, which may cause increased heart rate, high blood pressure, jitteriness, and anxiety.
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Why this happens
Fluvoxamine slows down the body's ability to break down dextroamphetamine (by blocking the CYP2D6 enzyme). Additionally, both drugs increase a chemical in the brain called serotonin; when levels get too high, it can cause dangerous side effects.
What you should do
Back to contentsYou should only take these together under close medical supervision. If your doctor prescribes both, watch for signs of serotonin syndrome, such as extreme sweating, shivering, fast heartbeat, muscle stiffness, or confusion. If you experience these, seek medical help immediately.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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