Can I take Codine and Diazepam together?

Why this happens

Both medicines are 'central nervous system depressants'. This means they both slow down the brain's activity. When taken together, their effects add up (a synergistic effect), which can dangerously suppress the part of the brain that controls breathing.

You should only take these two medicines together if they have been specifically prescribed by the same doctor who is aware you are taking both. If you feel unusually dizzy, sleepy, or have any trouble breathing, seek medical help immediately. Avoid alcohol completely while taking these medicines, as it will make these dangerous side effects much worse.

Combined use with alcohol or other sedatives

Taking these medicines together, or with alcohol, significantly increases the risk of fatal breathing difficulties and extreme sleepiness. Avoid alcohol and do not take other sedating medicines unless specifically directed.

Long-term use and dependency

These medicines are for short-term use only. Taking them for more than a few days can lead to physical addiction and severe withdrawal symptoms if stopped suddenly.

Alcohol

You must not drink alcohol while taking these medicines. Both codeine and diazepam cause drowsiness and slow down your breathing. Alcohol significantly increases these effects, which can lead to dangerous levels of sedation, breathing difficulties, and loss of consciousness.

Grapefruit juice

Avoid drinking large amounts of grapefruit juice. Grapefruit contains compounds that stop your body from breaking down diazepam properly. This can lead to higher levels of the medicine in your blood, increasing the risk of side effects like extreme sleepiness and shakiness.

Caffeine (Coffee, tea, energy drinks)

Try to limit your intake of caffeine. Diazepam is often prescribed to help with anxiety or sleep, whereas caffeine is a stimulant that can make you feel more anxious and awake. Caffeine can effectively cancel out the calming effects of diazepam.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.