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Can I take Atorvastatin and Riveroxaban together?

Drug interaction guide

Taking atorvastatin and rivaroxaban together may slightly increase the levels of rivaroxaban in your blood. This could potentially increase the risk of bleeding, such as bruising more easily, nosebleeds, or bleeding gums.

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Why this happens

Both drugs are processed by the same enzyme in the liver (CYP3A4) and a transport protein (P-gp). Because they 'compete' for these systems, atorvastatin can slow down the removal of rivaroxaban from your body, leading to slightly higher levels of the blood thinner.

This combination is commonly prescribed and is generally considered safe for most people. You do not usually need to change your dose, but you should be vigilant for signs of unusual bleeding or bruising. If you notice blood in your urine, black tarry stools, or a nosebleed that does not stop, seek medical advice promptly.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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