Skip to main content

Can I take Aspirin and Januvia together?

Drug interaction guide

Taking aspirin alongside Januvia (sitagliptin) may slightly increase the risk of your blood sugar levels dropping too low, a condition known as hypoglycaemia. While this is more common when aspirin is taken with other types of diabetes medications (like insulin or sulfonylureas), it is still possible with Januvia. Additionally, if you have any kidney issues, taking these together requires extra care as both drugs are processed by the kidneys.

Video picks for Drug interactions

Continue reading below

Why this happens

Aspirin belongs to a group of medicines called salicylates, which can naturally lower blood sugar levels and increase the body's sensitivity to insulin. Januvia works by increasing the amount of insulin your body produces after a meal. When used together, their combined effects can occasionally lead to blood sugar levels falling below the normal range.

For most people, this combination is safe, but you should be aware of the signs of low blood sugar (such as feeling shaky, sweaty, hungry, or dizzy). It is a good idea to monitor your blood sugar levels more closely when starting or changing the dose of aspirin. If you have kidney disease, consult your doctor before taking aspirin regularly, as they may want to check your kidney function.

Continue reading below

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Continue reading below

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
flu eligibility checker

Ask, share, connect.

Browse discussions, ask questions, and share experiences across hundreds of health topics.

symptom checker

Feeling unwell?

Assess your symptoms online for free

Sign up to the Patient newsletter

Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.

Please enter a valid email address

By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.