Can I take Aspirin and Januvia together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking aspirin alongside Januvia (sitagliptin) may slightly increase the risk of your blood sugar levels dropping too low, a condition known as hypoglycaemia. While this is more common when aspirin is taken with other types of diabetes medications (like insulin or sulfonylureas), it is still possible with Januvia. Additionally, if you have any kidney issues, taking these together requires extra care as both drugs are processed by the kidneys.
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Why this happens
Aspirin belongs to a group of medicines called salicylates, which can naturally lower blood sugar levels and increase the body's sensitivity to insulin. Januvia works by increasing the amount of insulin your body produces after a meal. When used together, their combined effects can occasionally lead to blood sugar levels falling below the normal range.
What you should do
Back to contentsFor most people, this combination is safe, but you should be aware of the signs of low blood sugar (such as feeling shaky, sweaty, hungry, or dizzy). It is a good idea to monitor your blood sugar levels more closely when starting or changing the dose of aspirin. If you have kidney disease, consult your doctor before taking aspirin regularly, as they may want to check your kidney function.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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