Can I take Apixaban and Diltiazem together?

Why this happens

Apixaban is broken down in the body by a specific enzyme (CYP3A4) and a transport protein (P-gp). Diltiazem slows down the activity of both this enzyme and the protein. Because the body cannot clear the apixaban as quickly as usual, the levels of the blood thinner rise.

You can usually take these medicines together, but your doctor should be aware of the combination. Watch closely for any signs of unusual bleeding or bruising. If you notice blood in your urine, black tarry stools, or a nosebleed that won't stop, seek medical advice immediately. Your doctor may occasionally need to adjust your dose depending on your age, weight, and kidney function.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.