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Can I take Amlodipine and Candesartan cilexetil together?

Drug interaction guide

Taking these two medicines together can cause your blood pressure to drop lower than usual. This might make you feel dizzy, lightheaded, or faint, especially when you stand up quickly. It can also increase the risk of your kidneys not working as well as they should.

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Why this happens

Both medicines work to lower blood pressure but in different ways: amlodipine relaxes the blood vessels directly, while candesartan blocks a hormone that makes blood vessels tighten. When used together, their effects add up (an additive effect), which is often a deliberate choice by doctors to treat high blood pressure that isn't controlled by one drug alone.

This is a common and effective combination, but you should be careful when first starting them or when your dose is increased. Rise slowly from sitting or lying down to avoid dizziness. Your doctor will likely monitor your kidney function and blood pressure through regular blood tests and check-ups. If you feel very dizzy, have a persistent headache, or notice you are passing less urine than normal, contact your doctor.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
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