Can I take Amlodipine and Bupropion together?

Why this happens

Amlodipine works by relaxing blood vessels to lower blood pressure. Bupropion can have unpredictable effects on the cardiovascular system; while it can sometimes raise blood pressure, it can also interact with the way your body processes other medications. There is also a small risk that bupropion could slightly increase the levels of amlodipine in your blood by interfering with certain liver enzymes (CYP3A4), though this effect is usually mild.

It is generally safe to take these together, but you should monitor your blood pressure more frequently when starting bupropion or changing your dose. To avoid dizziness, try to stand up slowly from a sitting or lying position. If you feel very dizzy, have a persistent headache, or notice your blood pressure readings are unusually high or low, contact your GP.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.