Can I take Amitriptyline and Naproxen together?

Why this happens

Amitriptyline belongs to a class of medicines that can affect how your blood platelets work. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that also thins the blood slightly and can irritate the lining of the stomach. When used together, these two effects combine, making bleeding more likely.

You should use this combination with caution. If you need to take them together, watch for signs of bleeding such as dark, tarry stools, coughing up blood, or vomit that looks like coffee grounds. If you have a history of stomach ulcers or are over 65, speak to your doctor before taking naproxen, as they may suggest a different painkiller or a medicine to protect your stomach.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.