Can I take Amitriptyline and Levothyroxine together?

Why this happens

Levothyroxine makes the heart more sensitive to the effects of catecholamines (natural chemicals like adrenaline). Amitriptyline increases the levels of these chemicals in the body. When combined, they can over-stimulate the heart. Additionally, both drugs can slow down the digestive system.

You can usually take these medicines together, but your doctor should monitor your heart rate and blood pressure, especially when starting treatment or changing doses. If you feel your heart racing, fluttering, or if you experience chest pain or severe dizziness, contact your doctor immediately.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.