Can I take Amitriptoline and Synjardy together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking amitriptyline with Synjardy (which contains metformin and empagliflozin) may interfere with your blood sugar control. Amitriptyline can sometimes cause blood sugar levels to rise or fall unexpectedly, which might make your diabetes medication less effective or increase the risk of a 'hypo' (low blood sugar).
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Why this happens
Amitriptyline can affect how the body handles glucose (sugar) and may alter the body's sensitivity to insulin. This can conflict with the way Synjardy works to lower blood sugar. Additionally, amitriptyline can sometimes mask the warning signs of low blood sugar, such as a fast heartbeat.
What you should do
Back to contentsYou should monitor your blood sugar levels more frequently when starting or changing the dose of amitriptyline. If you notice your readings are consistently higher or lower than usual, or if you feel unusually shaky, sweaty, or confused, contact your doctor. They may need to adjust your Synjardy dosage.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking fluoxetine with Abilify (aripiprazole) can significantly increase the amount of Abilify in your bloodstream. This makes you much more likely to experience side effects such as extreme sleepiness, restlessness (feeling like you cannot sit still), uncontrollable body movements (tremors or twitching), and dizziness. There is also a small but serious risk of a heart rhythm problem called QT prolongation.
Treatment and medication
Can I take Empagliflozin and Mirtazapine together?
There is no direct interaction between empagliflozin and mirtazapine. However, both medications can occasionally cause a drop in blood pressure when you stand up (postural hypotension). Taking them together might slightly increase the risk of feeling dizzy or light-headed.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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