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Can I take Allopurinol and Losec together?

Drug interaction guide

There is no known significant interaction between allopurinol and Losec (omeprazole). These two medicines are generally safe to take together.

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Why this happens

Allopurinol (used for gout) and Losec (a proton pump inhibitor used for acid reflux) are processed by different pathways in the body. They do not interfere with how each other is absorbed, broken down by the liver, or removed by the kidneys.

You can continue to take both medicines as prescribed by your doctor. It is usually best to take Losec in the morning before breakfast, while allopurinol is best taken after food to reduce the chance of an upset stomach.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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