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Can I take Allopurinol and Asprin together?

Drug interaction guide

Taking aspirin (especially at high doses) can make allopurinol less effective at lowering uric acid levels. This may increase the risk of a gout flare-up. Additionally, both medications can be tough on the stomach, slightly increasing the risk of irritation or indigestion.

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Why this happens

Aspirin can interfere with the way the kidneys remove uric acid from the body. Since allopurinol is taken to lower uric acid, aspirin can work against it. Furthermore, both drugs have the potential to irritate the lining of the stomach.

If you are taking low-dose aspirin (75mg to 150mg) for heart protection, you can usually continue taking it with allopurinol, but you should inform your doctor. Avoid taking high-dose aspirin (for pain relief) without consulting your doctor first, as it is more likely to interfere with your gout treatment. If you experience stomach pain or persistent indigestion, seek medical advice.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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