Can I take Adcal d3 and Bisoprolol together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking calcium supplements like Adcal-D3 alongside bisoprolol may slightly reduce the effectiveness of the blood pressure medication. In some cases, it could also lead to blood calcium levels becoming too high, which can affect how the heart beats.
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Why this happens
Calcium can sometimes interfere with how beta-blockers like bisoprolol work on the heart and blood vessels. Additionally, vitamin D (in Adcal-D3) helps the body absorb calcium; if calcium levels become too high (hypercalcaemia), it can counteract the heart-slowing effects of bisoprolol.
What you should do
Back to contentsIt is generally safe to take these together, but you should have your blood pressure and heart rate monitored regularly by your GP. If you experience symptoms like palpitations, extreme tiredness, or feeling sick, speak to your doctor. Try to take the two medicines at different times of the day (for example, bisoprolol in the morning and Adcal-D3 in the evening) to minimise any impact on absorption.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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