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Can I take Acetazolamide and Nefopam together?

Drug interaction guide

Taking acetazolamide and nefopam together may increase the risk of side effects such as a dry mouth, blurred vision, constipation, or difficulty passing urine. It may also increase the risk of feeling dizzy, drowsy, or confused.

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Why this happens

Both medicines have 'anticholinergic' properties. When used together, these effects can add up (an additive effect), making side effects more likely or more intense. Additionally, acetazolamide can make the urine more alkaline, which may slow down how quickly the body gets rid of nefopam, potentially leading to higher levels of the medicine in your system.

Use this combination with caution. If you notice significant dry mouth, blurred vision, severe constipation, or trouble urinating, speak to your doctor. Be careful when performing tasks that require alertness, such as driving, until you see how these medicines affect you together.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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