Can I take Acetaminophen and Rosuvastatin together?

Why this happens

Both drugs are metabolised (broken down) by the liver. Paracetamol can deplete a protective substance in the liver called glutathione. While they do not have a major direct interaction, the combined workload on the liver and the potential for paracetamol to slightly interfere with the enzymes that clear rosuvastatin can lead to higher levels of the statin in the body.

It is usually fine to take these two medicines together for short-term pain relief. However, you should avoid taking high doses of paracetamol regularly while on rosuvastatin. It is best to avoid or strictly limit alcohol when taking paracetamol, as combining them increases the risk of liver damage. If you notice any unusual muscle pain, tenderness, weakness, or yellowing of the skin or eyes, speak to your doctor.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.