Can I take Acetaminophen and Pomegranate fruit extract together?

Why this happens

Pomegranate contains compounds that can slow down certain liver enzymes (specifically CYP2E1 and CYP3A4) that are responsible for breaking down paracetamol. If these enzymes are blocked, the medicine stays in your system longer. Pomegranate also has mild antiplatelet effects, which can add to the blood-thinning effects of paracetamol.

It is best to use caution when combining these two. If you are taking paracetamol for a short period, a normal serving of pomegranate fruit is likely fine. However, if you are taking high-strength pomegranate extracts or supplements, you should speak to your doctor or pharmacist first. Always stick to the recommended dose of paracetamol and avoid or strictly limit alcohol, as both paracetamol and pomegranate can affect liver function.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.