Can I take Accrete d3 and Madopar cr together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking Accrete D3 at the same time as Madopar CR can significantly reduce how much of the Parkinson's medication your body absorbs. This could make your Madopar CR less effective, potentially causing your Parkinson's symptoms (like tremors or stiffness) to return or worsen.
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Why this happens
Accrete D3 contains calcium. Calcium can bind to the levodopa in Madopar CR in the digestive tract, forming a complex that the body cannot absorb into the bloodstream.
What you should do
Back to contentsYou should separate the doses of these two medicines by at least 2 to 3 hours. Do not stop taking either medication without speaking to your doctor or pharmacist first, as they may need to monitor your symptoms more closely.
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Important precautions
Back to contentsSudden onset of sleep
This medicine can cause you to fall asleep suddenly without warning. Do not drive or operate machinery if you experience excessive daytime sleepiness or sudden sleep episodes.
Impulse control disorders
You may experience unusual urges, such as addictive gambling, excessive eating or spending, or an abnormally high sex drive. Tell your doctor immediately if you or your family notice these behaviours.
Mental health changes
This medicine can cause hallucinations, confusion, or depression. Seek medical advice if you experience significant changes in your mood or see things that are not there.
Kidney stones/Kidney failure
Do not take this if you have severe kidney failure or a history of kidney stones, as the high calcium content can worsen these conditions.
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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