Can I take Abilify and Dapoxetine together?
Drug interaction guide
Originally published 14 Mar 2026
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Taking Abilify (aripiprazole) and dapoxetine together can increase the risk of a rare but serious condition called serotonin syndrome. It may also increase the risk of side effects like dizziness, sleepiness, and blurred vision. Additionally, dapoxetine can increase the levels of Abilify in your blood, making side effects more likely.
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Why this happens
Both drugs affect serotonin levels in the brain, which can lead to an over-accumulation (serotonin syndrome). Furthermore, dapoxetine can interfere with the liver enzymes (specifically CYP2D6) that break down Abilify, leading to higher levels of the medication in your system.
What you should do
Back to contentsYou should speak to your doctor before taking these two medicines together. If your doctor confirms it is appropriate for you, watch closely for signs of serotonin syndrome, such as high fever, agitation, muscle stiffness, or confusion. If you experience these symptoms, seek medical help immediately. It is also best to avoid or strictly limit alcohol, as it can worsen the drowsiness caused by both drugs.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Can I take Abilify and Fluoxetine together?
Taking fluoxetine with Abilify (aripiprazole) can significantly increase the amount of Abilify in your bloodstream. This makes you much more likely to experience side effects such as extreme sleepiness, restlessness (feeling like you cannot sit still), uncontrollable body movements (tremors or twitching), and dizziness. There is also a small but serious risk of a heart rhythm problem called QT prolongation.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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