Can I take 60 and Omeprazole together?
Drug interaction guide
Originally published 14 Mar 2026
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Omeprazole can significantly reduce the amount of 60 (nelfinavir) that your body absorbs. This can make the HIV medication much less effective, potentially leading to the virus becoming resistant to treatment.
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Why this happens
Nelfinavir needs a certain level of stomach acid to dissolve and be absorbed into the bloodstream. Omeprazole reduces stomach acid, which prevents nelfinavir from being absorbed properly.
What you should do
Back to contentsYou must not take omeprazole while you are taking nelfinavir. If you have symptoms of indigestion or acid reflux, speak to your doctor or pharmacist about safer alternatives that do not interfere with your HIV medication.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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