Can I take 500 and Permethrin together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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There are no known interactions between naproxen (Naprosyn 500) and permethrin.
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Why this happens
Naproxen is an anti-inflammatory tablet taken by mouth that works throughout the body, while permethrin is a cream or lotion applied to the skin that stays mostly on the surface. They are processed by the body in different ways and do not interfere with each other.
What you should do
Back to contentsYou can safely use these two medications together. Follow the specific instructions for the permethrin (usually leaving it on for a set number of hours) and take the naproxen with food to protect your stomach.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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