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Can I take 50 and Omnaptozol together?

Drug interaction guide

There is no known interaction between 50mg of sertraline (Zoloft) and omeprazole (the active ingredient in Omeprazole/Losec). However, omeprazole can sometimes increase the levels of sertraline in your blood, which might increase the risk of side effects like nausea, tremors, or feeling restless.

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Why this happens

Omeprazole can slow down the liver enzymes (specifically CYP2C19) that your body uses to break down sertraline. This can lead to slightly higher levels of sertraline staying in your system for longer.

It is generally safe to take these together, but you should monitor yourself for any new or worsening side effects from the sertraline. If you feel unusually anxious, shaky, or have a very upset stomach, speak to your doctor or pharmacist. Always take these medicines exactly as prescribed.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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