Can I take 5 and Levodopa together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Vitamin B6 (pyridoxine) can significantly reduce the effectiveness of levodopa. This means your Parkinson's symptoms, such as tremors or stiffness, may get worse or return even though you are taking your medication.
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Why this happens
Vitamin B6 speeds up the process of breaking down levodopa in the body before it has a chance to reach the brain. If the medicine is broken down too early, it cannot work properly to treat your symptoms.
What you should do
Back to contentsYou should avoid taking Vitamin B6 supplements (including multivitamins containing B6) while taking levodopa on its own. If you are taking a combination tablet (such as Sinemet or Madopar which contain carbidopa or benserazide), this interaction is less likely to happen, but you should still speak to your doctor or pharmacist before starting any new supplements.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
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Taking fluoxetine with Abilify (aripiprazole) can significantly increase the amount of Abilify in your bloodstream. This makes you much more likely to experience side effects such as extreme sleepiness, restlessness (feeling like you cannot sit still), uncontrollable body movements (tremors or twitching), and dizziness. There is also a small but serious risk of a heart rhythm problem called QT prolongation.
Treatment and medication
Can I take Acetaminophen and Trazodone together?
Taking paracetamol (acetaminophen) and trazodone together is generally considered safe, but there is a small risk of increased side effects. Both substances are processed by the liver, and in some cases, taking them together might slightly increase the levels of trazodone in your blood. This could make you feel more drowsy or dizzy than usual. Additionally, both medications can occasionally affect your liver function, so using them together over a long period requires caution.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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