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Can I take 5/40mg and Rosuvastatin together?

Drug interaction guide

Taking amlodipine and rosuvastatin together can increase the amount of rosuvastatin in your blood. This may increase the risk of side effects, particularly muscle pain, tenderness, or weakness (a condition called myopathy). In rare cases, this can lead to a serious muscle breakdown called rhabdomyolysis, which can damage the kidneys.

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Why this happens

Amlodipine can interfere with the way your body processes rosuvastatin. It may slow down the transport and breakdown of the statin, leading to higher levels of the medicine staying in your system for longer.

You can usually take these medicines together, but you should be aware of the increased risk of muscle problems. If you experience any unexplained muscle pain, tenderness, or weakness—especially if you also feel generally unwell or have a fever—contact your doctor immediately. Your doctor may want to monitor you more closely or adjust your dose.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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