Can I take 40 and Concerta together?
Drug interaction guide
Originally published 14 Mar 2026
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Taking alcohol with Concerta (methylphenidate) can cause the medication to be released into your bloodstream too quickly. This can increase the risk of side effects such as a racing heart, high blood pressure, anxiety, and sleep problems. Alcohol can also mask the effects of Concerta, making you feel less intoxicated than you actually are, which increases the risk of alcohol poisoning or accidents.
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Why this happens
Alcohol can alter how the body breaks down the 'extended-release' system of Concerta, leading to a sudden 'dump' of the drug into the system. Additionally, as a stimulant (Concerta) and a depressant (alcohol), they work against each other in the central nervous system, which can put extra strain on the heart and hide the signs of drunkenness.
What you should do
Back to contentsIt is best to avoid or strictly limit alcohol while taking Concerta. You should be aware that alcohol may affect you differently and could cause your blood pressure or heart rate to rise dangerously. Do not drink alcohol if you have any heart conditions.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking fluoxetine with Abilify (aripiprazole) can significantly increase the amount of Abilify in your bloodstream. This makes you much more likely to experience side effects such as extreme sleepiness, restlessness (feeling like you cannot sit still), uncontrollable body movements (tremors or twitching), and dizziness. There is also a small but serious risk of a heart rhythm problem called QT prolongation.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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