Can I take 3.75 and Cocodamol together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking zopiclone (3.75mg) and co-codamol together can cause extreme sleepiness, shallow breathing, and a high risk of accidental injury or falls. Both medicines slow down the central nervous system.
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Why this happens
Both drugs are 'depressants' that slow down brain activity. Zopiclone is a sedative-hypnotic, and co-codamol contains codeine (an opioid) and paracetamol. When used together, their sedative effects add up, significantly increasing the risk of severe drowsiness and respiratory depression (dangerously slow breathing).
What you should do
Back to contentsYou should speak to your doctor before taking these medicines together. If your doctor has prescribed both, take them exactly as directed and do not exceed the dose. Do not drink any alcohol while taking these medicines. If you feel unusually dizzy, confused, or have trouble breathing, seek medical help immediately. It is illegal to drive if your ability is impaired by these medicines.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
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Taking aspirin (75mg to 150mg) with Xigduo (which contains dapagliflozin and metformin) can increase the risk of your blood sugar dropping too low (hypoglycaemia). It may also increase the risk of a rare but serious condition called lactic acidosis, where too much acid builds up in your blood.
Treatment and medication
Can I take Acetaminophen and Trazodone together?
Taking paracetamol (acetaminophen) and trazodone together is generally considered safe, but there is a small risk of increased side effects. Both substances are processed by the liver, and in some cases, taking them together might slightly increase the levels of trazodone in your blood. This could make you feel more drowsy or dizzy than usual. Additionally, both medications can occasionally affect your liver function, so using them together over a long period requires caution.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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