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Can I take 15 and Sertraline together?

Drug interaction guide

Combining alcohol with sertraline can make you feel much more drowsy, dizzy, or lightheaded than usual. It can also impair your coordination, judgement, and reaction times. Furthermore, alcohol can worsen the symptoms of depression or anxiety that the sertraline is intended to treat, and in some cases, it may increase the risk of suicidal thoughts.

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Why this happens

Both alcohol and sertraline affect the central nervous system. When taken together, they have an 'additive effect', meaning they strengthen each other's sedative properties. Alcohol can also interfere with the way your brain processes serotonin, which is the chemical sertraline is designed to balance.

It is best to avoid or strictly limit alcohol while taking sertraline. Do not drive or operate machinery if you have consumed alcohol with your medication, as your coordination will be significantly impaired. If you feel your mood worsening or experience any unusual side effects, speak to your doctor or pharmacist.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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