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Can I take 100 and Powder for together?

Drug interaction guide

There is no known interaction between these two substances. Paracetamol is a painkiller and fever reducer, while Macrogol 3350 is an osmotic laxative used to treat constipation.

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Why this happens

These medicines work in different ways and are processed by different parts of the body. Paracetamol is absorbed into the bloodstream to target pain receptors, while Macrogol stays in the bowel to soften stools and is not absorbed into the body.

It is safe to take these two medicines together. Always follow the dosage instructions on the packaging for each product. If you are taking the Macrogol for chronic constipation, ensure you maintain good fluid intake. If your pain or constipation persists, consult your pharmacist or GP.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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