Can I take 1.0mg and Sertraline together?
Drug interaction guide
Originally published 14 Mar 2026
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Taking sertraline and warfarin together can significantly increase your risk of bleeding. This includes bruising more easily, nosebleeds, or more serious internal bleeding.
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Why this happens
Sertraline can interfere with how your body breaks down warfarin, leading to higher levels of the blood thinner in your system. Additionally, sertraline itself can affect how your blood platelets work, which adds to the blood-thinning effect of warfarin.
What you should do
Back to contentsYou must inform your doctor if you are taking both. They will likely need to monitor your blood clotting levels (INR tests) more frequently, especially when starting, stopping, or changing the dose of sertraline. Seek immediate medical help if you notice unusual bleeding, red or black stools, or severe bruising.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking aspirin (75mg to 150mg) with Xigduo (which contains dapagliflozin and metformin) can increase the risk of your blood sugar dropping too low (hypoglycaemia). It may also increase the risk of a rare but serious condition called lactic acidosis, where too much acid builds up in your blood.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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