Can I take 0mapresole and Amatryptoline together?

Why this happens

Omeprazole can slow down the liver enzymes (specifically CYP2C19 and CYP3A4) that are responsible for breaking down amitriptyline. Because the body cannot clear the amitriptyline as quickly as usual, the levels of the medicine build up in your system.

You should use this combination with caution. If your doctor has prescribed both, they may need to adjust your dose of amitriptyline. Monitor yourself closely for increased side effects. If you feel very dizzy, confused, or notice a fast or thumping heartbeat, contact your doctor immediately. It is also best to avoid or strictly limit alcohol while taking these medicines, as it can worsen drowsiness.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.