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Can I take 0.2mg and Hydrocortisone together?

Drug interaction guide

Taking fludrocortisone and hydrocortisone together can lead to an 'overdose' effect of steroid medication. This can cause your body to hold onto too much salt and water, leading to high blood pressure, swelling (oedema), and a loss of potassium. It can also increase the risk of side effects like stomach irritation, mood changes, and weakened bones.

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Why this happens

Both medicines are types of corticosteroids. Hydrocortisone is mainly used to replace cortisol (the 'stress hormone'), but it also has some salt-retaining effects. Fludrocortisone is a very potent salt-retaining steroid. When used together, their effects on your salt and mineral balance are added together, which can lead to an imbalance.

These two medicines are often prescribed together by specialists to treat conditions like Addison's disease. You should only take them together if specifically instructed by your doctor. Do not change your dose or stop taking them without medical advice. If you notice sudden weight gain, swelling in your ankles, or muscle weakness, contact your doctor.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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