synuclein beta
Last updated 29 Mar 2021
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The SNCB gene provides instructions for making a protein called beta-synuclein. The exact function of this protein is unknown, but it is likely involved in a process called synaptic plasticity. Synaptic plasticity is the ability of the connections between nerve cells (called synapses) to change and adapt over time in response to experience. This process is critical for learning and memory. Beta-synuclein may also prevent harmful accumulation of a similar protein called alpha-synuclein in nerve cells (neurons).
Normal function
The SNCB gene provides instructions for making a protein called beta-synuclein. The exact function of this protein is unknown, but it is likely involved in a process called synaptic plasticity. Synaptic plasticity is the ability of the connections between nerve cells (called synapses) to change and adapt over time in response to experience. This process is critical for learning and memory. Beta-synuclein may also prevent harmful accumulation of a similar protein called alpha-synuclein in nerve cells (neurons).
Conditions referring to this gene or chromosome
Other names
beta-synuclein
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Further reading and references
- synuclein beta; MedlinePlus, National Library of Medicine.
- Beyer K, Domingo-Sabat M, Santos C, Tolosa E, Ferrer I, Ariza A. The decrease of beta-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies. Brain. 2010 Dec;133(Pt 12):3724-33. doi: 10.1093/brain/awq275. Epub 2010 Oct 19.
- Brown JW, Buell AK, Michaels TC, Meisl G, Carozza J, Flagmeier P, Vendruscolo M, Knowles TP, Dobson CM, Galvagnion C. beta-Synuclein suppresses both the initiation and amplification steps of alpha-synuclein aggregation via competitive binding to surfaces. Sci Rep. 2016 Nov 3;6:36010. doi: 10.1038/srep36010.
- Ohtake H, Limprasert P, Fan Y, Onodera O, Kakita A, Takahashi H, Bonner LT, Tsuang DW, Murray IV, Lee VM, Trojanowski JQ, Ishikawa A, Idezuka J, Murata M, Toda T, Bird TD, Leverenz JB, Tsuji S, La Spada AR. Beta-synuclein gene alterations in dementia with Lewy bodies. Neurology. 2004 Sep 14;63(5):805-11. doi: 10.1212/01.wnl.0000139870.14385.3c.
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